1[1]Sirard CS,Kim C,Mirtsos P,et al.Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling[J].J Biol Chem,2000,275(3):2063-2070. 被引量:1
2[2]Hayashi HS,Abdollah Y,Qiu JC,et al.The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling[J].Cell,1997,89 (7):1165-1173. 被引量:1
3[3]Shi Y,Massague J.Mechanisms of TGF-beta signaling from cell membrane to the nucleus[J].Cell,2003,113 (6):685-700. 被引量:1
4[4]Chacko BM,Qin B,Correia JJ,et al.Theoop and C-terminal phosphorylation jointly define Smad protein trimerization[J].Nat Struct Biol,2001,8(3):248-253. 被引量:1
5[5]Nicolas FJ,Bosscher KD,Schmierer B,et al.Analysis of Smad nucleocytoplasmic shuttling in living cells[J].J Cell Sci,2004,117(18):4113-4125. 被引量:1
6[6]Massague J,Wotton D.Transcriptional control by the TGF -beta/Smad signaling system[J].Embo J,2000,19 (8):1745 -1754. 被引量:1
8[8]Sjoblom T,Yakymovych I,Heldin CH,et al.Smad2 suppresses the growth of Mv 1Lu cells subcutaneously inoculated in mice[J].Eur J Cancer,2004,40(2):267-274. 被引量:1
9[9]Langenfeld EM,Kong Y,Langenfeld J.Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5[J].Oncogene,2006,25(5):685-692. 被引量:1
10[10]Kang Y,Hebron H,Ozbun L,et al.Nkx2.1 transcription factor in lung cells and a transforming growth factor-betal heterozygous mouse model of lung carcinogenesis[J].Mol Carcinog,2004,40(4):212-231. 被引量:1
二级参考文献14
1Takanami I, Tanaka F, Hashizume T,et al. Roles of the transforming growth factor- beta 1 and type Ⅰ and Ⅱ receptors in the development of a pulmonary adenocarcinoma: results of an immunohistochemical study [J]. J Surg Oncol, 1997,64(4):262-267. 被引量:1
2Care- Riant T, Cuillrierl B, Beau-Faller M, et al. Association of genetic defects in primary resection adenocarcinoma revealed by targated allelic imba analysis[J] .Am J Respir Cell Mol Biol,2002, 27(4) :495 - 502. 被引量:1
3Hasegawa Y, Takanashi S, Kanehira Y, et al. Transforming growth factor- beta 1 level correlate with angiogenesis, tumor progression,and prognosis of patients with nonsmall cell lung carcinoma[J]. Cancer, 2001,91 (5) :964 - 971. 被引量:1
4Saji H, Nakamura H, Awut I, et al. Significance of expression of TGF - beta in pulmonar metastasis in non - small cell lung cancer tissues [J]. Ann Thorac Cardiovasc Surg ,2003, 9(5):295-300. 被引量:1
5Giles ED, Singh G. Role of insulin - like growth factor binding protein(IGFBPs) in breast cancer proliferation and metasta[J]. Clin Exp Metastasis, 2003,20(6) :481 - 487. 被引量:1