摘要
目的：评价国产注射用甲磺酸帕珠沙星治疗呼吸道细菌感染的临床疗效和安全性。方法：采用随机对照试验设计，以注射用盐酸左氧氟沙星为对照药，试验组用甲磺酸帕珠沙星注射剂，每次0．3g，bid，静脉滴注；对照组用盐酸左氧氟沙星注射剂，每次0．2g，bid，静脉滴注，疗程7～14d。结果：本研究共入选病例76例，剔除2例，可评价病例74例，试验组35例，对照组39例。试验组与对照组的痊愈率分别为65．7％（23／35）和56．4％（22／39），总有效率分别为94．3％（33／35）和97．4％（38／39），细菌清除率分别为74．2％（23／31）和74．3％（26／35），不良反应率分别为5．7％（3／35）和7．7％（3／39）。结论：国产注射用甲磺酸帕珠沙星治疗呼吸道细菌性感染疗效确切，安全性好。
Objective： To evaluate the efficacy and safety of pazufloxacin for injection in the treatment of respiratory tract bacterial infections. Methods：A randomized controlled clinical study was conducted to compare the efficacy and safety with that of lev-ofloxacin. Pazufloxacin and lev-ofloxac were administered intravenously at doses of 300 and 200 mg twice daily for 7 - 14 days. Results ：76 patients were enrolled in the study. 2 cases were excluded. 74 patients were divided into pazufloxacin and levofloxacin groups. The cure rates and over all clinical efficacious rates were 65.7% and 94.3% in the pazufloxacin group, and 56.4% and 97.4% in the lev-ofloxacin group respectively. The bacterial clearance rates of the two groups were 74.2% and 74.3% respectively. The incidence of adverse drug reactions of pazufloxacin was 5.7 % while that of levofloxacin was 7.7%. Conclusion：Domestic pazufloxacin for injection is effective and safe for the treatment of acute respiratory tract infections.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2007年第14期1122-1125,1129,共5页
Chinese Journal of New Drugs
