摘要
RNA干扰(RNAi)是指由双链RNA(dsRNA)所诱发的转录后水平上的基因沉默。RNAi通过小干扰RNA(siRNA)、重复相关siRNA(rasiRNA)和微小RNA(miRNA)而产生。由于RNAi对靶基因沉默作用的高度特异性和高效性,因此近年来RNAi用于肿瘤性疾病、感染性疾病、神经系统疾病等疾病的治疗研究是一个热点。虽然目前已有部分RNAi药物进入临床试验阶段,但是绝大部分的研究尚处于实验阶段,RNAi在临床上的实际应用尚需时日。
RNA interference （RNAi） is a method of post-transcriptional silencing of genes induced by doublestranded RNA （dsRNA） ,which can be generated by small interfering RNA （siRNA） ,repeat-associated small interfereree RNA （rasiRNA） and microRNA （miRNA）. Recently, RNAi has become a hot topic as a therapeutic method in neoplastic diseases, infectious diseases and nervous system diseases because of its high efficiency and specificity in silencing target genes. Although some of RNAi drugs have been used in clinical trials, most of them are still in the experimental phase. The application of RNAi in the clinical practice needs further study.
出处
《国际内科学杂志》
CAS
2007年第7期400-403,431,共5页
International Journal of Internal Medicine
