摘要
目的观察卡维地洛尔的临床疗效,探讨治疗剂量、方案及卡维地洛尔治疗小儿心内膜弹力纤维增生症(EFE)的安全性。方法卡维地洛尔治疗EFE患儿18例。观察治疗后临床症状改善、心率变化、心功能改善、不良反应及患儿对卡维地洛尔耐受量。结果卡维地洛尔治疗后临床症状明显改善,患儿射血分数(EF)、短轴缩短率(FS)、平均左室周径缩短率(Mvcf)显著提高,左室收缩期内径(LVDS)、左室质量(LVmass)、室间隔厚度(IVSs)明显降低。结论心功能Ⅱ～Ⅲ级EFE患儿对卡维地洛尔长期治疗具有良好耐受性。卡维地洛尔可降低心肌左室收缩末内径(LVDD)、IVSs和LVmass,抑制心室重塑,明显提高EFE患儿心功能。
Objective To observe the clinical effect and security of earvedilol on children with endocardial fibroelastosis （EFE）. Methods Eighteen children with EFE treatment with earvedilol. The improvement of clinical symptom, heart rate, heart function, side effect and maximal tolerance dose after treatment with earvedilol were observed. Results The clinical symptom was obviously improved; eiection fraction （EF） ,fractional shortening（ FS）, mean velocity of circumferential fiber（Mvef） were significantly increased, left ventrieular end- systolic dimension （LVDS） , left ventrieular mass（ LVmass）, interventrieular septal thickness （IVSs） were notably decreased after treatment with carvedilol. Conclusions The data indicates that earvedilol can significantly reduce left ventrieular diastolic dimension（ LVDD）, IVSs, and LVmass, inhibit the remodeling of ventricle,significantly elevate the heart function of EFE. So earvedilol is benefit and security on children with EFE.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第13期1012-1013,共2页
Journal of Applied Clinical Pediatrics
