摘要
探讨烧伤早期应用山莨菪碱对血液流变性的影响。沸水烫大鼠背部１５ｓ造成２５％Ⅲ度烧僵模型，烧伤后立刻给药；烧伤对照组静脉注射生理盐水１ｍｌ／ｋｇ，山莨菪碱治疗组静脉注射盐酸山莨菪碱５ｍｇ／ｋｇ。每组各于烧伤后１，３及６ｈ取血，另外高一正常组。
Objective:To evaluate the effects of anisodamine on hemorrheological changes, which had takenplace in rats subjected to postburn. Methods: The backs of rats were put into 100℃ water for 15 s to make the model of Ⅲ degree burn injury on 25% TBSA. Then saline (0. 9%,1 ml/kg) or anisodamine (5 mg/ kg) or nothing, served as control, experimental, and normal group respectively, was given to observe the changes of hemorrheology at the intervals of 1 h, 3 h, 6 h after burn. Results: After 1 h in control group whole blood viscosity at shear rate of 230s 1 and 5. 75s 1, RBC hematocrit, aggregation index of red cells, casson yield stress increased from 7. 11±0. 44 mPa·s, 15. 74±1. 07 mPa·s, 40. 00%±0. 00% , 2. 22± 0. 15, 14. 43±3. 55 to 7. 83±0. 42 mPa·s, 22. 62±1. 31 mPa·s, 47. 33%±4. 16%, 2. 89±0. 16, 34. 10± 5. 17 respectively (P<0. 01 or P<0. 05) . Electrophoretic rate of red cells (ERT) was eliminated from 3. 00±0. 05μm·cm 1 to 2. 90±0. 03μm·cm 1(P<0. 01). Anisodamine (5 mg/kg, iv) could markedly reverse the above five parameters to 6. 50±0. 45 mPa·s, 14. 78±5. 11 mPa·s, 40. 33%±4. 93%, 2. 26±0. 70,17. 20±1. 77 (P<0. 01 compared to saline control), and enhanced ERT to 2. 97±0. 06 um·cm 1. Conclusion: Anisodamine can improve the deformahility of RBC, decrease the aggregation of erythrocytes, so as to improve microcirculation, which is beneficial to prevent burn shock.
出处
《第四军医大学学报》
1997年第1期45-47,共3页
Journal of the Fourth Military Medical University
