摘要
目的研究持续性损伤与瞬间损伤所致断肢血管痉挛情况,以及解决断肢血管非节段性痉挛的方法。方法将80只兔子两侧后肢分别以瞬间损伤及持续性损伤两种方式离断,并在肢体离断前后抽取兔子血液测定血管紧张素Ⅱ(AngⅡ)变化情况,模仿肢体血流动力学,通过测定从离断肢体断端股动脉滴注等量生理盐水及血管舒张药物所需时间,观察两种损伤形式所致断肢血管痉挛情况引起的血流动力学改变及解除痉挛的较好方法。结果#"断肢后血液中血管紧张素Ⅱ增高(P<0.05);#$持续性损伤所致断肢血管液体流速较瞬间损伤所致断肢血管液体流速慢(P<0.05);#%滴注罂粟硷液、肝素液、利多卡因液、丹参液均有解痉作用(P<0.05),且滴注罂粟硷液效果最明显。结论创伤可以造成血液中血管紧张素Ⅱ增高;持续性损伤所致断肢血管痉挛情况较严重;再植前从断肢断端动脉滴注罂粟硷稀释液是解决断肢血管非节段性痉挛的较好方法。
Objective To study the vasospasm of amputated rabbits after continuous and transient damages,and seek a solution to non-segmental vasospasm in amputated rabbits. Methods The hind limbs of 80 rabbits were amputated by continuous and transient damages.The levels of plasma angiotensin Ⅱ （Ang Ⅱ） were determinded before and after amputation,the hemodynamics of limbs were imitated,time for drip of equivalent normal saline and vasodilator from femoral of the amputated limbs was measured,and the two defferent kinds of vasospasm and the management of spasticity by arterial drip were observed. Results （1）The level of Ang Ⅱ was higher after amputation （P〈0.05）. （2）The velocity of amputated limbs after continuous damages was slower than that of transient damages （P〈0.05）. （3）The effect of arterial drip of papaverine on spasmolysis was better than that of heparin,salviae and lidocine （P〈0.05）, Conclusion Damage can increase the plasma level of Ang Ⅱ ,the vasospasm of amputated limbs after continuous damages is severer than that of transient damages,and before replantation arterial drip of papaverine in amputated limbs is a good method for non-segmental vasospasm.
出处
《中国现代医药杂志》
2007年第7期52-53,共2页
Modern Medicine Journal of China
关键词
断肢
血管痉挛
解痉
Amputation Vasospasm Spasmolysis
