摘要
目的:观察停用环抱素A(CsA)和FK506期间内肾移植肺部感染患者的临床特点,为肾移植患者合并肺部感染提供临床诊断与救治新思路。方法:将以CsA或FK506为主要免疫抑制剂的肾移植患者68例分成CsA组和FK506组,对两组患者停药后血肌研正常的天数(肾功正常期)及血肌研、血粒细胞和淋巴细胞的结果进行比较。结果: CsA组36例患者停药后的肾功正常期平均为26.94±18.33天;FK506组32例患者停药后的肾功正常期平均为13.51±3.89天,CsA组患者肾功正常期明显长于FK506组(P<0.05);FK506组患者血粒细胞百分比呈下降趋势,淋巴细胞百分比均呈上升趋势,CsA组患者血粒细胞百分比走行趋势在肾功于常期内波动不大。肾功正常期内未见排斥反应发生。结论:肾移植肺部感染患者停药后存在一个客观的肾功正常期,且在此期间内停药不会引起排斥反应的发生,不影响患者肾功能。
Objective： TO observe the effects of cyclosporin （CsA） and tacrolimus （FK506） on the period of normal serum creatinine level after withdrawal of t inrenel allograft recipiants with pulmonary infection. Method： there were 68 renal recipients involved in this study, including 42 male and 26 female with average ages ineiuding 42 male and 26 female with average ages 44.32 ± 9.92 years old （24 - 61）, including 36 eases with CsA immunosuppressant treatment （CsA＋ MMF＋ Pred） and 32 eases with FK506 immunosuppressant treatment （FK506 ＋ MMF ＋ Pred） .To observe the time of normal serum creatinine and the changes of the level of blood serum creatinine and percentage of grenuloeyte and lymphocytic after withdrawal the .Results： The period is 26.94 ＋ 8.33days （CsA group） and 13.5 ± 3.89days （FK506 group） respectively, The period is significantly longer in CsA group than in FK506 group （P〈 0.05） . The percentages of grenulocyte in FK506 groups is descendent while the percentages of lymphocytic is ascenant. The fluctuation is not significantly in CsA group. It doesn＇t appear the rejection in two groups. Conclusion： There is an objective period of normal serum creatinine level after withdrawal of immunosuppressant in renal allograft recipients with pulmonary infection. The withdrawal can not effect the renal function without increasing the rejection in recipients.
出处
《福州总医院学报》
2007年第1期47-49,共3页
Journal of Fuzhou General Hospital
基金
福建省科技计划重点项目基金(2005Y017)
关键词
肾移植
肺部感染
肾功正常期
环抱素A
PK506
Renal transplantation
Pulmonary infection
Period of normal creatinine
CsA
FK506
