摘要
目的:观察复方醋酸环丙孕酮(复方CPA)治疗多囊卵巢综合征(PCOS)的临床疗效和安全性。方法:对35例多囊卵巢综合征患者应用复方CPA治疗3个周期,观察用药前后临床特征、血清性激素水平、卵巢超声相的变化以及副反应和停药后的情况。结果:34例PCOS患者恢复月经,并且有2例妊娠。多毛和痤疮评分明显下降(P<0.01)。血清各性激素水平均有明显下降,雌二醇(E2)、黄体生成素(LH)、促卵泡素(FSH)、LH/FSH、睾酮(T)、硫酸脱氢表雄酮(DHEAS)、游离睾酮指数(FAI)下降显著(P均<0.01),性激素结合球蛋白(SHBG)明显增加(P<0.01)。双侧卵巢体积及双侧卵泡数目明显减少(P均<0.01),双侧卵泡直径也减小(P<0.05)。副反应总发生率为71.4%。结论:复方醋酸环丙孕酮可很好改善多囊卵巢综合征患者的高雄激素症状及内分泌状况,对恢复排卵和青春期患者也有很好疗效。
Objective： To investigate the clinical efficacy and safety of compound cyproterone acetate （CPA） in the treatment of polycystic ovary syndrome （PCOS）. Methods： Thirty-five proven PCOS patients received compound cyproterone acetate （CPA） for 3 cycles. Serum sex hormone and transvaginal pelvic ultrasonography were determined before, 3 cycles after treatment. Results： 34 patients had regular uterine bleeding during CPA therapy and 2 pregnancies achieved. Hirsute and ache score decreased significantly （P 〈0.01）. Serum estradiol （E2）, luteinizing hormone （LH）, follicle stimulating hormone （FSH）, LH/ FSH, Testosterone （T）, dehydroepiandrosterone （Ds） and free androgen index（FAI）decreased significantly （P 〈0.01）, while sex hormone binding globin （SHBG） increased significantly （P 〈0.01）. Bilateral ovarian volumes shrunk and follicle numbers decreased significantly （P 〈0.05-0.01）. Conclusion： CPA has antiandrogenic effects on PCOS patients and improve their edocrine and ovulation induction. It is also effective in treatment of adolescent girls with PCOS .
出处
《新疆医科大学学报》
CAS
2007年第6期626-629,共4页
Journal of Xinjiang Medical University
