摘要
目的:探讨肺源性心脏病(肺心病)中医证型与左心功能变化的关系。方法:应用无创心功能检测仪测定130例不同证型肺心病患者的左心功能指标,并对各证型的证候积分与心功能指标进行相关分析。结果:心排血指数(CI)、心排血量(CO)、每搏指数(SI)、每搏量(SV)、左心做功指数(LCWI)、左心做功量(LCW)的数值大小在各证型中由高到低依次为:痰浊蕴肺证>痰热壅肺证>气阴两虚证>阳虚水泛证;外周血管阻力(SVR)、外周血管阻力指数(SVRI)由高到低依次为:阳虚水泛证>气阴两虚证>痰热壅肺证>痰浊蕴肺证;肺心病阳虚水泛证加速度指数(ACI)及速度指数(VI)最低,痰浊蕴肺证最高。肺心病痰热壅肺证及痰浊蕴肺证证候积分与心功能指标CI、SI、收缩时间比率(STR)无相关性(P均>0.05);气阴两虚证证候积分与CI、SI呈较弱负相关(r1=-0.379,r2=-0.345,P均<0.05);阳虚水泛证证候积分与STR呈显著正相关(r=0.523,P<0.01)。结论:心功能指标CI、SI、LCWI、SVRI、SVR、STR等是反映中医证型动态演变有价值的指标。
Objective： To investigate the relationship between syndrome patterns of traditional Chinese medicine （TCM）in chronic obstructive pulmonary disease （COPD） with chronic cor pulmonale （CCP）and left cardiac function. Methods： To measure the left heart function targets of 130 patients with CCP and different syndrome patterns by noninvasive cardiac function meter. Regression analysis was applied to show the relationship between the syndrome score points of TCM and the left heart function. Results： The values of cardiac index （CI）, cardiac output （CO）, systolic index （SI）, stroke volume （SV）, left cardiac work index （LCWI）, left cardiac work （LCW） became gradually lower and lower in the sequence as follows： Tanzhuo Yunfei （痰浊蕴肺证）〉 Tanre Yongfei （痰热壅肺证）〉 deficiency of both Qi and Yin （气阴两虚证）〉 edema caused by deficiency of Yang （阳虚水泛证）; reversely, while the values of systemic vascular resistance index （SVRI） and systemic vascular resistance （SVR）, according to the above sequence, gradually became higher and higher. Among the four groups, the values of acceleration index （ACI） and velocity index （VI） were the lowest in edema caused by deficiency of yang group, while they were the highest in tanzhuo yunfei. Single factor regression analysis showed that in tanre yongfei and tanzhuo yunfei group, the syndrome score points of TCM were not correlated with any one of the levels of CI, SI and systolic time ratio （STR） （all P〉0. 05）; in deficiency of both qi and yin group, the syndrome score points of TCM were negatively correlated with either of the levels of CI or SI （rl =- 0. 379, rz =- 0. 345, both P^0.05） ; in edema caused by deficiency of yang, the points were obviously positively correlated with the level of STR （r： 0. 523,P〈0.01）. Conclusion： Some of parameters of noninvasive cardiac function （CI, SI, LCWI, SVRI, SVR, STR） may be of value to reflect the development of syndrom
出处
《中国中西医结合急救杂志》
CAS
2007年第4期241-244,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
上海市重点学科基金资助项目(Y0302-11)
关键词
肺疾病
阻塞性
慢性
心脏病
肺源性
中医证型
左心功能
chronic obstructive pulmonary disease
chronic cor pulmonale
syndrome patterns of traditional Chinese medicine
left heart function
