摘要
目的探讨鞘内注射吗啡在晚期癌痛患者疼痛治疗中的有效性和安全性。方法7例晚期癌痛患者经皮下泵鞘内注射吗啡,观察患者的吗啡用量、镇痛效果、生活质量、并发症及生存时间。结果患者的吗啡使用量为36．0～80．0mg/d。鞘内注射吗啡后的生存时间为23～215d,中位生存时间为111d;未出现与阿片类药物使用相关的其他并发症。鞘内注射吗啡后的中位疼痛视觉模拟评分为2分,较注射前的8分显著降低(P＜0．05)。鞘内注射吗啡后的中位生活质量满意度评分为4．6分,较注射前的1．7分显著升高(P＜0．05)。结论鞘内注射吗啡技术用于晚期癌痛患者的疼痛治疗安全、有效。
Objective To appraise the effectiveness and safety of intrathecal morphine delivery via subcutaneous port for advanced cancer pain relief. Methods Seven patients were given long term intrathecal morphine delivered via subcutaneous port for cancer pain relief. The dosage of morpine, analgesic effect, side effects, satisfaction and quality of life were observed. Results The maximum dosage of morphine was 36.0-80.0 mg/d. Mean VAS after morphine delivery was 1. 86. The median duration of intrathecal morphine application till death was 111.1 days. Quality of life was improved significantly （P 〈 0.05） and side effects were rare after intrathecal morphine delivery. Conclusion Intrathecal morphine delivery via subcutaneous port for cancer pain relief is effective and safe. （ShanghaiMedJ, 2007, 30：422-424）
出处
《上海医学》
CAS
CSCD
北大核心
2007年第6期422-424,共3页
Shanghai Medical Journal
