摘要
目的为了研究异位性皮炎患者皮损趋化性细胞因子受体CXCR3在异位性皮炎的发病过程中的作用。方法采用荧光定量聚合酶链反应检测21例异位性皮炎患者皮损内和18例健康对照者正常皮肤中CXCR3的表达水平;采用直线相关回归分析方法分析CXCR3mRNA的表达与异位性皮炎病情严重程度的关系。结果异位性皮炎患者皮损内CXCR3mRNA表达水平明显高于对照组(P<0.01);异位性皮炎患者皮损内CXCR3mRNA表达水平与异位性皮炎病情严重程度呈正相关性(r=0.67092,P=0.0009)。结论趋化性细胞因子受体CXCR3可能参与了异位性皮炎的发病过程。
Objective To investigate the role of chemokine receptor CXCR3 in patients with atopic dermatitis. Methods The expression of CXCR3 mRNA was measured by fluorescent quantitative polymerase chain reaction, and the relationship between CXCR3 mRNA expression and the disease severity （graded according to SCORAD index system） was assessed by correlation analysis. Results CXCR3 mRNA expression was significantly higher in patients with atopic dermatitis than in healthy control subjects （P〈0.01）, and showed obvious positive correlation with SCORAD index system. Conclusion These data suggest an important role of CXCR3 in the development and progression of atopic dermatitis.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第7期1084-1085,共2页
Journal of Southern Medical University
