摘要
目的是探讨美比欧疤痕平治疗烧伤后皮肤疾痕，使之迅速软化的作用机理。方法是选健康小鼠40只，背部皮肤去毛后，以2mol／LNaOH烧伤1分钟，造成深见度皮肤烧伤。伤后2周局部疲痕形成。随机分为二组，I组为对瘢痕不作处理作为对照；Ⅱ组为应用美比欧疤痕平进行治疗。治疗2周处死，取烧伤处皮肤进行HE及改良的Mas－son染色。结果Ⅰ组上皮层增生、角化，胶原纤维增生、排列紊乱，并使人肌组织内，可见大量炎性细胞浸润；Ⅱ组病理组织学与正常皮肤近似。结论美比欧疤痕平具有抑制炎性反应、改善组织供血、抑制上皮及胶原纤维增生、抑制皮肤病痕形成、促进上皮修复的功能。
The purpose of this research is to illustrate the mechanism of the scar softening effect of MEBO Scar Lotion. 40 heaIthy mice were depilated on the back and were burned by 2 mol/liter caustic soda for one minute, and deep second degree burn wounds were resulted. Scars formed one week post burn. The burned mice were divided in random into two gruops.Mice in the first group did not receive any treatment,while those in the second gruop were treated with MEBO Scar Lotion. After two weeks of treatment, the mice were sacrificed. The skin in the burned area were stained using HE and improved Masson stain and examined. The results revealed that in the first group,the animals had epithelial proIiferation,keratinization, collagenous fibre proliferation and arrangement disorder. Muscular tissue was invaded. There were a large amount of inflammatory cell infiItration. ln the second group, the results of pathological tissue examinationswere nearly the same as the normal skin. Conclusion: MEBO Scar Lotion has the effects of inhibiting the inflammatory reaction, improving blood supply to the tissue and inhibiting proliferation of epithelial tissue and collagenous fiber. Therefore, it prevents skin scar formation and promotes the repair of epithelial tissue.
出处
《中国烧伤创疡杂志》
1997年第2期6-6,5,共2页
The Chinese Journal of Burns Wounds & Surface Ulcers
