摘要
目的检测P33ING1b在乳腺癌组织及癌旁正常组织中的表达情况,探讨P33ING1b在乳腺癌发生发展中的意义。方法运用免疫组化方法检测86例乳腺癌标本(乳腺癌组)及19例癌旁正常组织(对照组)中P33ING1b、P53、雌二醇受体(ER)、孕酮受体(PR)的表达情况。结果乳腺癌组与对照组均有P33ING1b的表达。乳腺癌细胞P33ING1b阳性表达率下降[66.3%(57/86)],与对照组[94.7%(18/19)]比较有显著性差异(P<0.05)。P53、ER、PR在癌组织中的表达分别为58.1%、59.3%、62.8%。P33ING1b表达与P53、ER、PR表达呈正相关(r=0.295,r=0.379,r=0.780;P均<0.05);与肿瘤大小、腋窝淋巴结有无转移呈负相关(r=-0.165,r=-0.498;P均<0.05),与年龄、组织分级、远处转移及生存期无明显相关性。结论P33ING1b的表达可作为乳腺癌鉴别的一个标记物。支持P33ING1b的丢失可能是乳腺癌分化、发生的一个重要的分子事件的观点。
Objective To detect the expression of P33^ING1b in breast cancer and juxtacancerous tussue,and to approach the significance of P33^ING1b gene expression in the happening and development of breast carcinoma. Methods The expression of P33^ING1b, P53, oestrogen receptor （ER）, and progesterone receptor （PR） of 86 primary invasive breast cancers and 19 juxtacancerous tis- sue were detected with immunohistochemical methods. Results The expression of P33^ING1b in breast carcinoma group and control group were positive and the expression of P33^ING1b in breast carcinoma tussue was extremely decreased, significantly different from the other group （P〈 0.05）. The positive rates of p53, ER, and PR in breast carcinoma tussue were 58. 1%, 59.3% and 62.8% respectively. The expression of P33^ING1b was positively correlation with the level of P53,ER and PR （r=0. 295,r=0. 379,r=0. 780%P〈0.05）,and the expression of P33^ING1b was negatively correlation with tumor size and lymph node metastases （r=0. 165, r=0. 498. P〈 0.05） ,and there was no correlation with age,tissue grade,distant transfer and life span. Conclusion P33^ING1b expression could be used as a marker of differentiation in breast cancer. These results support the view that loss of P33^ING1b may be an important molecular event in the differentiation and pathogenesis of breast cancer.
出处
《江西医学院学报》
CAS
2007年第3期13-15,19,共4页
Acta Academiae Medicinae Jiangxi
基金
江西省卫生厅课题(20043050)
