摘要
目的调查乙肝病毒B基因亚型在我国的分布情况。方法采用聚合酶链反应-限制性片段长度多态性（PCR—RFLP）法并结合测序法，对来自全国7个中心的共511份B基因型感染血清样本进行了检测。结果511份B基因型样本经亚型分析，确定全部为Ba亚型，未发现Bj亚型的存在。结论流行于我国南方及北方地区的乙肝病毒B基因型毒株绝大部分为Ba亚型，Bj亚型非常罕见。
Objective To investigate the distribution of hepatitis B virus （HBV） genotype B subgenotype in China. Methods A cohort of 511 patients with chronic HBV genotype B infection, collected from 7 centers across China, were analyzed by using polymerase chain reaction-restriction fragment length polymorphism （PCR- RFLP） or nucleotide sequencing. Results For the 511 patients, only subgenotype Ba was identified and subgenotype Bj was not found. Conclusion In China, subgenotype Ba was the most prevalent HBV strains, while subgenotype Bj was very rarely found.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2007年第2期111-113,共3页
Chinese Journal of Experimental and Clinical Virology
基金
国家自然科学基金（30500434）
