摘要
目的：研究转化生长因子β＿１（ＴＧＦ－β＿１）与病毒性肝炎肝纤维化发生的关系。方法：对５４例病毒性肝炎肝组织进行ＴＧＦ－β＿１以及α－平滑肌肌动蛋白（α－ＳＭＡ）、Ⅳ型胶原（Ⅳ－Ｃ）免疫组织化学研究，并检测其中４９例血清Ⅲ型前胶原肽（ＰⅢＰ）、层粘蛋白（ＬＮ）、透明质酸（ＨＡ）、Ⅳ－Ｃ等。结果：随着肝纤维化程度的加重，ＴＧＦ－β＿１在肝组织中的表达逐渐明显。在慢性肝炎重度、肝硬变慢性重型肝炎中的表达强度明显高于慢性肝炎中度、轻度及急性肝炎。同时ＴＧＦ－β＿１在肝组织中的表达与血清ＰⅢＰ、ＬＮ、ＨＡ、Ⅳ－Ｃ以及α－ＳＭＡ和Ⅳ－Ｃ在肝组织中的表达呈明显的正相关。结论：ＴＧＦ－β＿１通过刺激贮脂细胞，大量合成细胞外间质，最终导致肝脏的纤维化。
Aim: To study the relationship between the expression of transforming growth factor-β1(TGF- β1) in the liver tissues of viral hepatitis and liver fibrosis Methods: The expressions of TGF-β1, collagen type Ⅳ (Ⅳ-C) and α-smooth muscle actin (α-SMA) in the liver tissues were detected by immutnohistochetnistry. the levels of serum pro-collagen Ⅲ peptide (P Ⅲ P), laminin (LN) , hyaluronilc acid (HA) and Ⅳ -C were also exatnined. Resutts: Tlbe expressioct of TGF-β1 in the groups of liver cirrhosis and chroctic severe hepatitis was higher than those in the groups of acute and other chronic hepatitis (P<0.01 ). High correlation were found between the expression of TGF-β1 and the levels of PⅢP, LN. HA, Ⅳ - C in the sera, and between the expressions of TGF-β1 and α-SMA, Ⅳ - C . Conclusion : The expresdons of TGF-β1 correlated closely with liver fibrosis of viral hepatits.
出处
《中华肝脏病杂志》
CAS
CSCD
1997年第2期66-68,共3页
Chinese Journal of Hepatology
关键词
转化生长因子
病毒性肝炎
肝纤维化
Transforming growth factor-β Vinl hepatitis Liver fibrosis lmmuatohistochemistry
