摘要
１９９３年６月—１９９６年６月间，作者观察了羟基喜树碱（ＨＣＰＴ）合并氟脲嘧啶（５－ＦＵ）、醛氢叶酸（ＣＦ）治疗晚期大肠癌１９例，并与５－ＦＵ／ＣＦ方案治疗晚期大肠癌１６例相比较，有效率分别是３６．８％（７／１９）和１２．５％（２／１６），虽然治疗组有效率较高，但经统计学处理无显著性差异。两组均未见严重的毒副反应。作者认为，ＨＣＰＴ可选择性抑制ＴｏｐｏＩ，针对性地消除肿瘤耐药，与５－ＦＵ／ＣＦ联合治疗晚期大肠癌，初步观察其近期疗效较好，无毒性增加，值得临床进一步研究。
From Jun 1993 to Jun 1996,5 Fluorouracil(5 FU)and folinic acid(CF)with or without Hydroxy1 Camptothecin(HCPT)treated 35 evaluable patients with advanced colorectal cancer.There were 19 patients in 5 FU/CF+HCPT(study group)and 16 patients in 5 FU/CF(control group).The response rates of the two groups were 36.8%(7/19)and 12.5%(2/16),respectively.Mild to moderate side effect were found.There was no significantly difference between the two groups,but the response rate of the study group was higher. HCPT is Topoisomerasel(Topol)repressor,and could eliminate drug resistance of colorectal cancer,The results indicated that when combined with 5 FU/CF,HCPT can improve the response rate on advanced colorectal cancer.
