摘要
研究 μ型阿片受体激动剂羟甲芬太尼 （Ｏｈｍｅｆｅｎｔａｎｙｌ ＯＭＦ）及 δ阿片受体激动剂 Ｄ－Ｓｅｒ－２－Ｌｅｕ－Ｅｎｋｅｐｈａｌｉｎ-Ｔｈｒ （ＤＳＬＥ）对麻醉大鼠心血管和呼吸系统的影响。两药均用微量注射法注入内侧视前区（ｍｅｄｉａｌ ｐｒｅｏｐｔｉｃ ａｒｅａ， ＭＰＯ）。结果：注射 ５ ｎｍｏｌ ＯＭＦ可引起血压下降、心率减慢；注射 １０ ｎｍｏｌ ＯＭＦ引起血压、心率上升；注射δ型阿片受体激动剂 １０ ｎｍｏｌ ＤＳＬＥＴ引起血压下降，但对心率无明显影响。 ２０ ｎｍｏｌ纳洛酮可桔抗ＯＭＦ、ＤＳＬＥＴ的上述效应。上述剂量的ＯＭＦ、ＤＳＬＥＴ均对大鼠呼吸无明显影响。结论：结果提示，内侧视前区注射ＯＭＦ和ＤＳＬＥＴ引起的心血管效应是由阿片受体介导的，ＯＭＦ低剂量降压，高剂量升压；ＤＳＬＥＴ降压。
PURPOSE To investigate cardiovascular and respiratory effects of it opiate receptor agonist ohmefentanyl (OMF) and δ opiate receptor agonist D-Ser-2-Leu-Enkephalin-Thr (DSLET) in anesthetized rats. METHODS The both agents were microinjected into medial preoptic area (MPO). RESULTS OMF 5 nmol produced hypotension and bradycardia, OMF 10 nmol caused pressor responses and tachycardia. DSLET 10 nmol caused decrease in blood pressure, but no effect on heart rate. The effects mentioned above were all antagonized by naloxone 20 nmol. No effect on respiration was observed at these doses. CONCLUSIONS The cardiovascular effects of OMF and DSLET microinjectd into MPO. are mediated by opiate receptors, low dose of OMF causes hypotension and bradycardia, high dose of OMF produces pressor response and tachycardia; DSLET produces hypotension.
出处
《上海医科大学学报》
CSCD
1997年第1期14-16,共3页
Journal of Fudan University(Medical Science)
基金
国家自然科学基金(3937023)资助
关键词
阿片受体激动剂
血压
心率
呼吸
μ agonist
δ agonist
medial preoptic area
blood pressure
heart rate
respiration.
