摘要
采用免疫组织化学LSAB法对68例膀胱移行上皮癌标本中的抑癌基因p16表达产物进行检测，29例显示表达阳性，且阳性表达率在恶性度低、浅表性和未复发膀胱肿瘤中较高，Ⅰ级与Ⅱ级、Ⅰ级与Ⅲ级、Tis～T1与T2～T4、及复发与未复发比较均有显著性差异（P＜0．05）。表明p16蛋白表达与膀胱移行上皮癌的分化程度、浸润深度及预后有关。
Expression of p16 gene was studied in 68 patients with transitional cell cancer using immunohistochemical technique. Twenty nine cases showed positive staining of p16 protein which was more frequently expressed in low grade,non-invasive and non-recurrent bladder tumors. There was a significant difference of p16 protein expression between grade Ⅰ and grade Ⅱ and so was between grade Ⅰ and grade Ⅱ + grade Ⅲ (P<0. 05). Our result shows that expression or non-expression of p16 gene is closely related to the malignant potential,Invaslveness and prognosis of bladder cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第4期272-275,共4页
Chinese Journal of Clinical Oncology
