摘要
目的建立猪冠状动脉再狭窄模型,并用血管内超声(IVUS)进行评价。方法选择健康小型猪9头,在左前降支中段植入金属裸支架[支架/血管直径=(1.1～1.2)/1.0],术后第28天复查造影、IVUS,并行组织形态学检查观察再狭窄情况。结果4头猪在支架植入2 h内死亡,5头猪完成实验后复查,定量冠脉造影(QCA)示支架植入后血管直径为(2.90±0.26)mm,比植入前基础血管直径[(2.52±0.31)mm]明显增大(P=0.001);随访期血管直径[(1.20±0.77)mm]较植入后血管直径明显减小(P=0.002),直径狭窄百分比为(60.2±23.5)%,支架内再狭窄率为60%。组织形态学检查示管腔面积与支架内面积相比明显减小[(1.29±1.02)mm2vs(6.04±1.21)mm2,P<0.01],平均面积狭窄百分比为(77.9±19.7)%。IVUS检查结果类似[管腔面积(1.67±1.17)mm2vs(5.85±0.94)mm2,P<0.01],平均面积狭窄百分比为(71.0±23.3)%。两种检查手段测得的支架内面积、管腔面积、新生内膜面积和平均面积狭窄百分比相比差异无统计学意义(P>0.05)。结论成功建立猪冠状动脉再狭窄模型,IVUS检查可作为猪冠脉再狭窄模型支架内再狭窄的评价手段。
Objective To develop a porcine restenosis model of coronary artery, and to evaluate it by intravascular ultrasound （IVUS）. Methods Nine bare metal stents were implanted into left anterior descendings （LADs） of nine swines [ stent/vessel = （1. 1 -1.2）/1.0]. Then 28 days later,the in-stent restenosis were measured by quantity coronary angiography （QCA） , IVUS and histomorphology respectively. Results After 28 days five swines were undergone re-examination. QCA showed that the post-stenting vessel diameter increased markedly compared with base vessel diameter [ （2.90 ± 0.26）mm vs （2.52 ± 0.31 ）mm, P = 0. 001 ]. The fol- low-up vessel diameter [ （ 1.20 ± 0.77 ） mm ] was diminished markedly compared with the post-stenting vessel diameter （P = 0. 002）, and the percentage of diameter stenosis was （60.2 ± 23.5 ） %, while the in-stent restenosis rate was 60%. Histomorphometric results showed that the lumen area was diminished remarkably compared with the in-stent areas [ （ 1.29±＋ 1.02） mm^2 vs （6.04 ± 1.21 ） mm^2 ,P 〈0.01 ] ,and the average percent area of stenosis was （77.9 ± 19.7 ）%. IVUS analysis yielded similar results [ the lumen area （ 1.67 ± 1. 17） mm^2 vs （5.85 ± 0.94） mm^2,P 〈 0.01 ] ; the average percent area of stenosis （71.0 ± 23.3 ） %. Respective area of instent,lumen,neointimal and the average percent area of stenosis acquired by IVUS analysis were consistent with histomorphometric results （P 〉 0.05 ）. Conclusions A porcine restenosis model of coronary artery was successfully produced in which in-stent restenosis can be evaluated by IVUS in a porcine restenosis model.
出处
《现代医学》
2007年第4期253-256,共4页
Modern Medical Journal
基金
江苏省社会发展计划项目(BS2004026)
江苏省卫生厅资助项目(Z200320)
关键词
冠状动脉模型
血管再狭窄
血管内超声
新生内膜
猪
coronary artery model
restenosis
intravascular ultrasound
neointimal
swines
