摘要
心脏在很多病理情况下都可以发生心室重构。心室重构实际上是一个涉及到心脏的心肌细胞、非心肌细胞、基质及血管的复杂过程。非心肌细胞引起心肌细胞肥大的机理目前尚无统一的认识。但有许多研究证明，非心肌细胞是通过局部旁分泌产生激素实现其作用的。其巾主要是肾素一血管紧张素一醛固酮系统。AngⅡ促使心肌细胞肥大、非心肌细胞增殖及胶原合成增多。是否还有其他的多种因子参与这一过程以及AngⅡ是通过何种信号途径影响心肌细胞的结构和功能尚待进一步研究阐明。
Ventricular remodeling may exist in many pathological conditions. Ventricular remodeling is a multiple process involved in myocytes and nonmyocytes. Several studies provided that nonmoycyte can promote ventricular hypertrophy by secreting angiotensin Ⅱ. Angiotensin Ⅱ can promote myocyte enlarging and nonmyocyte proliferating. It is not confirmed that if other factors being involved in the mechanism of ventricular remodeling.
出处
《世界急危重病医学杂志》
2007年第4期1978-1981,共4页
internationl journal of emergency and critical care medicine
