摘要
目的:探讨IL-18、IL-10和IFN-γ水平变化与系统性红斑狼疮(systemic lupus erythematosus,SLE)发病的关系。方法:采用ELISA法检测SLE患者52例、对照组48例血清IL-18、IL-10和IFN-γ的水平。结果:SLE组IL-18(265.7±78.3)pg/mL、IL-10(78.2±2.2)pg/mL、IFN-γ(22.4±9.2)pg/mL较正常对照组IL-18(184.1±63.6)pg/mL、IL-10(18.3±6.4)pg/mL、IFN-γ(12.5±5.1)pg/mL有高度显著性差异(P<0.01),且活动期SLE患者IL-18(382.7±156.4)pg/mL、IL-10(90.8±12.9)pg/mL与非活动组IL-18(91.3±48.6)pg/mL、IL-10(45.1±15.4)pg/mL之间比较有高度显著差异(P<0.01),活动期IFN-γ(26.8±9.8)pg/mL和非活动期患者IFN-γ(18.9±9.1)pg/mL之间比较无显著性差异(P>0.05)。结论:SLE患者IL-18、IL-10水平增高,且与疾病活动性有关,可作为判断疾病疗效的监测指标。SLE患者血清IFN-γ水平也显著提高,表明在SLE患者中,参与炎症反应可能既有Th1型细胞因子,也有Th2型细胞因子。
Objective： To investigate the correlation between the changes of serum IL-18, IL-10 and IFN-γ and systemic lupus erythematosus （SLE）. Methods： The levels of IL-18,IL-10 and IFN-γ from 52 patients with SLE and 48 normal control were determined with sandwich ELISA. Results.The levels of IL- 18（265. 7±156.4）pg/mL,IL-10（78.2±2.2） pg/mL and IFN-γ （22.4±9.2）in SLE were significant higher than those of in control group （P〈0.01）. And there were significant differences between active SLE patients IL-18（382. 7±156.4） pg/mL and IL-10 （90.8±12. 9） pg/mL） and inactive patients IL-18（91.3± 48.6） pg/mL and IL-10（45.1±15.4） pg/mL）（P〈0. 01）. The level of IFN-γ in both active and inactive SLE was no significant difference （P〉0.05）. Conclusion： The levels of IL-18 and IL-10 are increased in active patients with SLE and may play a significant role in the curative effect of SLE. There was significant difference between SLE group and control group in level of IFN-γ. Abnormally high expression of Th1 and Th2 cytokines might contribute to the inflammatory damages of SLE.
出处
《海南医学院学报》
CAS
2007年第2期120-122,124,共4页
Journal of Hainan Medical University
