摘要
采用以5－氟尿嘧啶（5－FU）、人血清白蛋白为材料制成的微球，注入实验兔髂内动脉，测定髂内动脉注入微球后的血药浓度及膀胱组织药物浓度。同时对5只兔以同法注入等量常规5－FU作为对照。结果：制成的微球直径35～75μm，含药量均为10％。体外研究微球24h释药量为35％，实验组血药高峰浓度为23．8μg／ml，明显低于对照组（P＜0．05），出现时间也比对照组晚30min，注药后4h兔膀胱组织中5－FU的量则是33．68μg／g，显著高于对照组（P＜0．01）。认为注入5－FU微球于肿瘤区，发挥其局部化疗的作用，明显优于单纯药物动脉内注入法。5－FU微球注入法是一种有希望的抗肿瘤疗法，为今后的研究方向提供了依据。
5-Fu concentrations in blood and bladder tissue were detected to study the preparation and pharmacological characteristics of 5-Fu microspherein 10 rabbits infused with 5-Fu microsphere and 5 rabbits (the control group) infused in the same dosage via iliac artery. The reswlts showed that the 5-Fu microsphere ranged from 35 to 75μm in diameter and the content of 5-Fu in 5-Fu microsphere is about 10%. The peak of 5-Fu concentration in serum of the experimental group was 23. 8 μg/ml much lower than that of the control (P<0. 05). 5-Fu concentration in bladder tissne of the experimental group was 33. 68μg/g much bigher than that of the control (P <0. 01). The experiment indicated 5-Fu microsphere topical chemotherapy might be effective.
出处
《临床泌尿外科杂志》
1997年第1期44-46,共3页
Journal of Clinical Urology
