摘要
采用单纯放疗、手术加放疗和放疗加化疗对３３例肺癌脑转移进行了治疗。放疗采用全脑加（或）局部放疗，全脑照射量３５～５１Ｇｙ，局部加量１０～２０Ｇｙ，肿瘤量为３５～６１Ｇｙ／１８～３０ｆ／（３０～７０ｄ），化疗采用ＶＭ２６１００ｍｇ，１、３、５或ＭｅＣＣＮＵ１００～１５０ｍｇ．ｐｏ１次，放疗前或放疗后用。结果：全组中位生存期７．５月，手术加放疗为１４月，放疗加化疗１０月，单纯放疗５．５月，均提高生存期，但以前两者为佳（Ｐ＜０．０５）。本组一年生存率为４４％，近期疗效、生存期、脑转移治后复发与病理类型、转移灶数目无关（Ｐ＞０．０５），与治疗方式、剂量有关（Ｐ＜０．０５）。
The 33 patients with brain metastasis of lung cancer were treated by radiotherapy alone(R) or radiotherapy combinated with chemotherapy (R+C) or surgery plus radiotherapy(S+R) The radiotherapy was given with the dose of 35—51 Gy to whole brain then followed by DT 10-20 Gy booster The chemotherapy was given with VM 26 100 mg iv d1,d3,d5,or MeCCNU 100-150 mg po before or after radiotherapy Result:The median survival stage of the whole group was 7 5 months The survival stage of the R,R+C, S+R group were 5 5, 10,14 months respectively The survival stage of treated patients was longer than the patients who were not treated. But the radiotherapy combinated with surgery or chemotherapy were batter than radiotherapy alone (P<0 01) The one year survival rate of the group was 44% The respones of the short term curative effect, survival stage, the erccurence rate were not relationship to the histopathology, the number of metastasis (P>0 05), but it related to the methold of therapy and the irradiation dose (P<0 05)
出处
《贵阳医学院学报》
CAS
1997年第1期60-62,76,共4页
Journal of Guiyang Medical College
