摘要
目的：分析丙戊酸钠治疗癫痫患者的血药浓度监测结果，指导临床合理用药。方法：采用荧光偏振免疫法对198例癫孕患者进行丙戊酸钠血药浓度监测。结果：达到有效血药浓度（50～100μg·mL^-1）113例次（57．07％），低于有效血药浓度64例次（32．32％），高于有效血药浓度21例（10．61％）。结论：丙戊酸钠在体内血药浓度个体差异大，建议临床使用时需个体化给药。
OBJECTIVE ： To analyze the monitoring results of the serum concentration of sodium valproate in the treatment of epileptic patients so as to guide its clinical rational administration. METHODS： The serum concentrations of sodium valproate of 198 epileptic patients were determined by fluorescence polarization immunoassay （FPIA）. RESULTS： 113 cases （57.07 % ） reached effective serum concentration, 64 （32.32 % ） were lower and 21 （ 10.61% ） were higher than effective serum concentration. CONCLUSION： Serum concentrations of sodium valproate varied greatly in epileptic patients, therefore, it is suggested that an individualized administration scheme be applied in its clinical use.
出处
《中国医院用药评价与分析》
2007年第3期201-202,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
丙戊酸钠
血药浓度监测
癫痫
荧光偏振免疫法
Sodium valproate
Serum drug concentration monitoring
Epilepsy
Fluorescence polarization immunoassay
