摘要
利用自体血凝块颅内埋藏法复制家兔脑血肿模型,在造模后不同时间测定血气值、脑组织水、伊文斯蓝(EB)、脑指数及病理形态学方面的改变。结果显示:脑血肿形成后,动物有过度通气,脑组织含水量、脑指数明显增加,血脑屏障(BBB)受损,通透性增强,有EB透过BBB。选用醒脑健神胶囊进行治疗,能显著改善通气异常,降低BBB通透性,减轻脑组织蓝染范围与程度,促进脑组织内血肿的吸收,对脑水肿的防治和BBB的保护有明显的作用。
The experimental cerebral hematoma models were produced by injecting outogenous clot in the rabbit.We observed the influences of “Xing Nao Jian Shen”Capsule on blood gas,brain index,content of water,natrium,kalium,calcium,magnesium in brian tissues and change of cerebrovascular permeability,histomorphology at the third day,seventh day,fourteenth day after cerebral hematoma.The results showed that in the pathological group brain index and content of water,ventilation of lung,natrium,calcium of brain tissue were increased progressly,cerebrovaslar permeability were raised obviously,especially in the side of hematoma(right brain).It was found that “Xing Nao Jian Shen”Capsule could reduced cerebral edema.Brain index,content of water,natrium,calcium,in brain tissue and cerebrovascular permeability,hyperventilation after cerebral hematoma were all less than pathologicl group and closed to control group.Therefore it was advantageous in the treatment of encephaledema resulting by experimental cerebral hematoma.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
1997年第1期21-23,共3页
Journal of Apoplexy and Nervous Diseases
基金
国家"八五"攻关科研基金
关键词
醒脑健神胶囊
脑血肿
血脑屏障
药物疗法
Xing Nao Jian Shen”Capsule Cerebral hematoma Cerebral edema Blood Brain Barrier Rabbits