摘要
为了研究大肠癌表皮生长因子受体(EGFR)和 p53蛋白表达与病理特征和预后的关系。应用免疫组化检测 EGFR 和 p53对61例大肠癌的表达。结果提示:正常大肠粘膜未发现 EGFR 和 p53阳性表达,而两者在大肠癌均有较高表达(77.04%和55.7%)。EGFR 表达与大肠癌 Dukes 分期有关(P<0.05)。p53表达与大肠癌分化程度及 Dukes 分期有关(P<0.05)。大肠癌生存率随 EGFR 和 p53表达增高而降低,其中两者4年生存率>65%表达组均明显低于<25%组(P<0.05),EGFR-LI 和 p53-LI 与生存期均有明显负相关。结论表明:EGFR 和p53表达与大肠癌的进展程度有关,该两项指标对大肠癌临床诊治和预后的评估有重要价值。
In order to study the clinicopathological characteristics and prognostic significance of epidermal growth factor receptor (EGFR) and p53 protein expression,immunohistochemical staining was performed on paraffin-embedded sections of 61 colorectal carcinomas.Results showed EGFR and p53 positive rate was higher (77.04% & 55.75%) in colorectal carcinomas as compared to normal mu- cosa EGFR exprssion was related to Dukes Stage (P<0.05),and p53 expression was relate to differen- tiation and Dukes stage (P<0.05) In the expression of EGFR and p53 among≤25% group,26-65% group and >65% group,survival rate decreased with the incrasing positive rate There was a significant relation (>65% group vs ≤25% group P<0.05 in 4-year survival rate.There was an inverse correla- tion bewteen EGFR-LI and Survival rate,so was p53-LI These results suggestthat expression of EGFR and p53 were relate to the development of colorectal carcinmoma,and EGFR and p53 play an important role in clinical diagnosis,treatment and prognostic evaluation.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1997年第1期16-18,共3页
Chinese Journal of Cancer
关键词
大肠肿瘤
表皮生长因子
受体
P53蛋白
病理
预后
Colorectal carcinoma
Epidermal growth factor receptor
p53 Clinicopathology
Prognosis
