摘要
慢性阻塞性肺疾病（COPD）的发病涉及到多种炎症基因在肺内的表达,组蛋白去乙酰化酶（HDAC）在调控炎症基因的表达中起至关重要的作用。HDAC2的表达和活性在COPD患者肺组织匀浆及肺泡巨噬细胞中明显减少,与肺功能下降程度和气道炎症强度相关;HDAC表达和活性减低部分参与了COPD患者糖皮质激素抵抗的发生;低浓度茶碱可以恢复HDAC的活性,从而增加对糖皮质激素的敏感性。
Multiple inflammatory genes expressing in the lung are involved in the pathogenesis of chronic obstructive pulmonary disease（COPD）. Histone deacetylases （HDACs） play a critical role in the regulation of these genes. In the lung homogenate and alveolar macrophages of COPD patients, there is a significant reduction in HDAC2 activity and expression, which is correlated with the decrease of lung function and the extent of airway inflammation, and similar mechanism may partly account for steroid resistance in COPD. The reduction of HDACs activity may be restored by low concentration of theophylline, which may increase response to steroid treatment in COPD.
出处
《国际呼吸杂志》
2007年第13期985-988,共4页
International Journal of Respiration
