摘要
目的探讨断乳后低钙膳食对高脂膳食大鼠肥胖的影响。方法80只刚断乳雄性Wistar大鼠按体重随机分为2组,分别给予低钙或正常钙膳食3周,然后以正常饲料喂养3周。第6周末各组动物又随机分成2组,分别喂饲高脂饲料和基础饲料,观察肥胖发生情况。结果断乳后低钙膳食大鼠食用高脂饲料后体脂含量、血脂、瘦素水平显著升高,高密度脂蛋白(HDL)、游离三碘甲状腺原氨酸(FT3)水平显著降低。结论断乳后给予低钙膳食可能促进高脂膳食大鼠肥胖的发生。
Objective To explore the effects of low calcium diet after weaning on obesity in rats induced by high fat diet. Methods After weaning, male Wistar rats were randomly divided into two groups according to their body weights. One group was fed with a basic diet, the other was fed with a low calcium diet for 3 weeks. Then they were fed with basic diet for another 3 weeks. At the 6^th month, the rats of each group were further randomly divided into 2 groups. One group was fed with a high fat diet;the other was fed with a basic diet. The status of obesity of the rats was observed. Results Compared with rats with basic fed diet, the body fat content of rats with low calcium diet after weaning significantly increased and the level of serum lipids, the level of leptin also increased significantly（ P 〈 0.05 ）, the level of HDL （high density lipoprotein）, FT3 （free triiodothyronine）decreased（ P 〈 0.05 ）. Conclusion The tendency of obesity in rats with low calcium diet after weaning were more obvious than rats with normal diet after being fed a high fat diet.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2007年第7期769-771,共3页
Chinese Journal of Public Health
基金
国家自然科学基金(30471445)
关键词
断乳
肥胖
血脂
激素
weaning
obesity
serum lipids
hormone
