摘要
目的:观察大耳白兔吸入全氟异丁烯(PFIB)后其动脉血血气、血常规、空腹血糖,以及血清中炎症标志物乳酸脱氢酶和碱性磷酸酶活力的变化规律,旨在发现对全氟异丁烯中毒早期诊断具有重要意义的诊断指标。方法:采用兔头部动态暴露装置,在PFIB 300 mg/m3条件下暴露20 min,经兔耳中央动脉连续采血进行分析。结果:在全氟异丁烯染毒前后,实验兔血常规、空腹血糖的变化不甚明显;在动脉血血气分析中仅发现雌性动物动脉氧分压在染毒后12和24 h出现轻微下降;雄性动物血清中乳酸脱氢酶(LDH)含量在染毒后即刻显著性升高,其血清中碱性磷酸酶(AKP)含量在染毒后12 h显著性升高。结论:血常规、空腹血糖在PFIB中毒后无明显变化,动脉血血气的改变对于PFIB中毒早期诊断的意义不大,而血清中LDH和AKP的含量变化对PFIB中毒早期诊断具有一定的参考价值。
Objective： To find some diagnostic criteria for perfluoroisobutylene （PFIB） intoxication by observing the changes of blood gas, blood routine tests, fasting blood sugar and inflammatory marker in rabbits exposed to PFIB. Methods： Rabbits were exposed to gaseous PFIB （300 mg/m3） for 20 minutes in a flow-past head exposure system. The blood samples were collected serially from rabbit central ear artery. Results： No changes of the blood routine tests and fasting blood sugar were observed. The arterial oxygen pressure of female rabbits decreased slightly only at 12 h and 24 h after PFIB inhalation, and the concentrations of LDH and AKP in serum of male rabbits increased significantly after PFIB inhala- tion. Conclusion： The changes of blood gas, blood rountine tests and fasting blood sugar are not worthy for early diagnosis of PFIB-induced acute lung injury, while the changes of the activity of LDH and AKP in serum have some reference value for early diagnosis of induced acute lung injury.
出处
《军事医学科学院院刊》
CSCD
北大核心
2007年第3期256-258,278,共4页
Bulletin of the Academy of Military Medical Sciences
