摘要
目的:研究血清脱氢表雄酮(DHEA)水平与老年性疾病的关系。方法:565例老年男性,平均年龄79.99±7.73岁,检测其血清脱氢表雄酮水平,分析血清DHEA水平与一些老年性疾病的关系。结果:血清DHEA水平与年龄呈负相关(r=-0.37,P<0.01)。60～70岁年龄组老年人DHEA的平均浓度为9.78±3.85μmol/L,70～8()岁年龄组为3.12±2.32μmol/L,80岁及以上组为1.84±1.22μmol/L。糖代谢异常者血清DHEA浓度降低,在糖尿病或糖耐量无异常组血清DHEA浓度为1.62±1.20μmol/L,非糖尿病或糖耐量异常组血清DHEA浓度为2.63±2.22μmol/L,两组有显著差异。高血压病及高脂血症对DHEA的影响并不显著,高血压病组血清DHEA浓度为2.55±2.09μmol/L,非高血压病组血清DHEA浓度为2.17±1.86μmol/L;高脂血症组血清DHEA浓度为2.69±1.77μmol/L,非高脂血症组血清DHEA浓度为2.34±2.08μmol/L,两组之间均无显著差异。结论:DHEA与年龄密切相关,随着年龄的增加,血清DHEA浓度下降。糖尿病或糖耐量异常者DHEA水平较低,高血压病对DHEA水平影响不显著可能与药物因素有关。
Objective： To evaluate the correlation between serum dehydroepiandrosterone（DHEA） level and aging associated diseases. Methods：Determined the serum concentration of DHEA in 565 elderly men ,and to analysed the correlation of DHEA with aging and some diseases associated with aging. Results： DHEA level showed negative correlation with aging（r = 0.37, P〈0.01）. The concentration of DHEA in men aged between 60 and 70 years old was 9.78 ± 3.85 μmol/L, while the concentration of men aged between 70 and 80 years old and that of aged 80 and above was 3.12 ± 2.32 μmol/L and 1.84 ± 1.22 μmol/L respectively. The concentration of serum DHEA was also associated with glycometabolism. The concentration of DHEA was 1.62 ± 1.20 μmol/L in eldly with diabetes or IGT, while the concentration of DHEA in eldely without diatetes or IGT was 2. 63 ± 2.22 μmol/L. DHEA level showed no correlation with either hypertention or dyslipidemia in our observation. Conclusion： Serum DHEA level declines with aging, and is low in eldly men with diabetes or IGT. Antihypertention drugs may intervention the correlation between hypertention and the level of DHEA.
出处
《中国临床医学》
北大核心
2007年第3期431-433,共3页
Chinese Journal of Clinical Medicine
关键词
脱氢表雄酮
男性
衰老
性激素
Dehydroepiandrosterone
Male
Aging
Sex hormones
