摘要
目的：评价伊曲康唑对老年口咽部白色念珠菌感染的疗效。方法：患口咽部白色念珠菌感染的老年病人３１例，男性１９例，女性１２例；年龄６６±ｓ８ａ。分治疗组１６例，对照组１５例。前者用伊曲康唑１００ｍｇ，ｐｏ，ｂｉｄ，疗程３ｗｋ；后者用酮康唑２００ｍｇ，ｐｏ，ｂｉｄ，疗程４ｗｋ。结果：伊曲康唑组临床有效率为１００％，酮康唑组为９３％，２组比较无显著性差异（Ｐ＞０．０５）。但伊曲康唑的显效时间、疗程较酮康唑短（Ｐ＜０．０１）。伊曲康唑的不良反应比酮康唑少而轻。结论：伊曲康唑为治疗老年口咽部白色念珠菌感染的有效药物。
AIM: To study the curative effect of itraconazole in the treatment of oral candidiasis in aged. METHODS: Thirty-one elderly patients (M 19, F 12, age 66±s 8 a) with oral cadidiasis were randomly divided into 2 groups. Sixteen patients of treatment group were given itraconazole 100 mg, po, bid for 3 wk, while the other 15 patients of control group were given ketoconazole 200 mg, po, bid for 3 wk. RESULTS: The effective rate of itraconazole and ketoconazole were 100% and 93%, respectively (P>0.05). The time to effectiveness and the course of treatment were both shorter in treatment group than those in control (P<0.01). The adverse reactions were also lighter in treatment group than in control. CONCLUSION: Itraconazole is indeed a satisfactory medicine in treating oral candidiasis in aged.
出处
《新药与临床》
CSCD
北大核心
1997年第1期30-31,共2页
关键词
伊曲康唑
酮康唑
白色念珠菌感染
老年人
口咽部
itraconazole
ketoconazole
Candida albicans
oral candidasis
microbial sensitivity tests
aged
