摘要
目的探讨慢性肾功能衰竭患者血浆微炎症反应相关细胞因子IL-10、IL-18的水平及意义。方法分别采用ELISA和RIA法检测患者血浆IL-10、IL-18、CRP含量,并与健康对照组比较。结果CRF患者血浆IL-10(58·49±21·82)μg/L、IL-18(310·58±182·73)ng/L、CRP(7·48±1·35)mg/L均分别明显高于健康对照组的(31·13±5·93)μg/L、(45·31±196·69)ng/L、(3·36±0·71)mg/L(P<0·01)。结论CRF患者体内存在细胞因子参与的微炎症反应。
Objective To investigate the changes and clinical significance of serum IL - 10, IL - 18 and CRP in patients with chronic renal failure（CRF）. Methods Using ELISA or RIA, serum IL - 18, CRP and IL - 10 were measured in 60 patients with CRF and 35 controls. Results Serum levels of IL - 10[ （58.49 ±21.82） μg/L] ,CRP[7.48 ± 1.35） mg/El and IL - 18[ （310. 58 ± 182. 73） ng/L ]were significantly higher in patients with CRF than those[ （31.13±5.93 ）μg/L, （45.31 ± 196. 69） ng/L, （3.36 ±0. 71 ） mg/L] in controls（ P 〈0. 01 ）. Conclusion There is microinflamation response in patients with chronic renal failure.
出处
《医药论坛杂志》
2007年第11期24-25,共2页
Journal of Medical Forum
