摘要
Althuis等曾研究了一系列新的3,4-二氢-4-氧嘧啶并[4,5-b]喹啉-2-羧酸抗敏剂的结构与活性的关系,得到比DSCG高400倍的药理活性.但对3-位N上取代基结构变化对药理活性的影响尚未见报道。为此,我们合成了3-位上具有不同取代基的一系列3,4-二氢-4-氧嘧啶并[4,5-b]喹啉(Ⅲ)。
Syntheses of N-Substituted 3, 4-dihydro-4-oxopyrimido[4, 5-b]quinolines which were achieved by reaction of N-Substituted 2-aminoquinoline-3-carboxyamides with formamide are described in detail. The structures of 20 new compounds have been confirmed by element analysis, IR and 1H NMR.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1990年第5期532-533,共2页
Chemical Journal of Chinese Universities
