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安理申治疗阿尔茨海默病和轻度认知功能障碍的疗效观察 被引量:6

Effect of donepzil on Alzheimer's disease and mild cognitive impairment
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摘要 目的评估安理申治疗轻、中度阿尔茨海默病(Alzheimer's disease,AD)和轻度认知功能障碍(mildcognitive impairment,MCI)的疗效。方法采用配对双盲法进行。42例AD和32例MCI患者入组,其中37例用安理申片5mg,每晚1次;另37例用吡拉西坦片800mg,3次/d,疗程均为12周。结果安理申组总有效率70%,吡拉西坦组为40%,差异有统计学意义(P<0.01)。安理申组AD患者简易智能状态量表(MMSE)及日常生活功能水平量表(FAQ)分数较治疗前明显改善(P<0.05、P<0.01);安理申不良反应轻。结论安理申治疗AD和MCI安全有效。 Objective To evaluate the therapeutic effects of donepzil on Alzheimer's disease and mild cognitive impairment. Methods Thirty-seven patients with Alzheimer' s disease and mild cognitive impairment in treatment group were treated with donepzil(5 rag) ,one time per day for 12 weeks; other 37 patients were treated with piracetam (800mg) , three times per day. Results The total effective rate of donepzil group(70% ) was signficantly higher than that of piracetam group(40% )(P 〈0. 01 ). The scales of Mini-mental State and daily life function of patients with Alzheimer's disease were improved after donepzil treatment. Adverse reactions of donepzil was mild. Conclusions Donepzil has a safe and therapeutic effect on Alzheimer's disease.
出处 《实用老年医学》 CAS 2007年第3期187-188,共2页 Practical Geriatrics
关键词 安理中 吡拉西坦 阿尔茨海默病 轻度认知功能障碍 donepzil piracetam Alzheimer's disease mild cognitive impairment
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  • 1Davis KL,Moks RC,Marin D,et al.Cholinergic markers in elderly patients with early signs of Alzheimer's disease[J].JAMA,1999,281(15):1401-1406. 被引量:1
  • 2王德生,张守信主编..老年性痴呆[M].北京:人民卫生出版社,2001:523.
  • 3David SG.Clinical experience with donepezil hydrochloride:a case study perspective[J].Adv Therapy,1997,14(2):305-311. 被引量:1
  • 4Thomsen T,Bickl U,Fischer JP,et al.Tolerance and inhibition of cholinesterases by galanthamine in healthy volunteers and Alzheimers patients[J].J Neurol Transm,1991,198(1):59-63. 被引量:1

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