摘要
目的探讨不同期别宫颈癌术前介入治疗的效果。方法对30例Ⅰb2-Ⅲb期宫颈癌患者,采用Seldinger技术,行超选择性子宫动脉灌注化疗,加行子宫动脉栓塞治疗。化疗药物采用博莱霉素、顺铂及异环磷酰胺三药联合。栓塞剂采用明胶海绵颗粒。3周后进行妇科检查,判断动脉化疗及栓塞的治疗效果,决定下一步治疗方案。对手术治疗者再根据术中情况及术后病理结果进一步评价介入治疗的效果。结果介入治疗总有效率93.3%（28/30）,临床完全缓解率13.3%（4/30）。其中,Ⅰb2-Ⅱb期有效率为100%（27/27）,Ⅲb期有效率为33.3%（1/3）。有效的患者主要表现为宫颈局部病灶缩小明显。介入治疗后手术率为86.7%（26/30）,病理完全缓解率6.7%（2/30）。结论超选择性子宫动脉灌注化疗加栓塞,对Ⅰb2-Ⅱb期宫颈癌患者有较好的疗效,能有效地缩小肿瘤体积,有利于手术进行,故在临床上可根据患者的情况选择性应用。
Objective To investigate effect of interventional therapy before surgical treatment of cervical carcinoma in different stage. Methods Thirty patients with stage Ⅰb2-Ⅲb cervical carcinoma were treated by super selective uterine artery chemotherapy and uterine artery embolization followed by chemotherapy. Cisplatin, bleomycin and ifosfomide were the drugs in the combination chemotherapy regimen. Pelvic examination was performed 3 weeks late to estimate the effect of the therapy and to determine the followed treatment measures. The effect of chemotherapy and embolization was assessed again for patients undergoing surgery after operation. Results The overall response rate of interventional therapy for cervical cancer was 93.3% （28/30） ,clinical complete response rate was13.3% （4/30）. The response rates were 100% in 27 stage Ⅰb2-Ⅱb and 33.3% in stage Ⅲb（1/3） patients. The main sign for the response patients is cervical tumor decreasmy. The successful rate of operation was 86.7% （26/30） after transcatheter therapy and 6.7% pathologic complete response rate was achieved. Condusion Transcatheter super selective uterine artery chemotherapy and embolization is effective in the treatment of stage Ⅰb2-Ⅱb cervical carcinoma, it should be used for some selective patients before surgery.
出处
《中原医刊》
2007年第12期9-11,共3页
Central Plains Medical Journal
关键词
宫颈肿瘤
子宫动脉化疗
子宫动脉栓塞
Cervical neoplasms
Uterine artery chemotherapy
Uterine artery embolization
