摘要
目的探讨托吡酯(TPM)治疗Tourette综合征的临床效果及合适剂量。方法Tourette综合征患儿79例予TPM口服,剂量从0.5mg/(kg.d)开始,渐增加至3mg/(kg.d),2次/d,于治疗前及治疗后3个月应用耶鲁抽动症整体严重程度量表(YGTSS)评估疗效,观察药物不良反应。结果除1例出现药物不良反应和2例剂量增加至3mg/(kg.d)无效果而退出观察外,余76例于治疗后2～4周症状均获显著改善,治疗前后YGTSS分值:运动性抽动分数19.63±3.09和5.05±1.74,发声性抽动分数18.95±2.56和4.82±1.94,综合损害分数24.21±5.89和10.42±3.69,严重度总分62.21±5.81和22.26±4.81。治疗前后YGTSS各分值比较均有显著差异(Pa<0.001)。76例中3例出现疲乏,1例嗜睡,2例注意力不集中,继续用药后症状消失,均不影响治疗。结论TPM治疗Tourette综合征疗效好,所需剂量小,不良反应轻,可作为治疗该病的首选药物之一。
Objective To explore the therapeutic effects and dose of Topiramate （TPM） in children with Tourette syndrome （TS）. Me- thods Seventy - nine children with TS were given oral TPM, which were treated with Topiramate [ 0.5 - 3.0 mg/（ kg · d） ,twice a day ]. The therapeutic effects were assessed using Yale Global Tic Severity Scale （YGTSS） before and 3 months after treatment and the side - effects of the drugs were observed ,Results The differences of YGTSS scores before and after treatment, motertic score（ 19.63 ± 3.09 vs 5.05 ± 1.74）, vocaltic score[ （18.95 ±2.56） vs （4.82 ±1.94） ] ,global scole score[ （24.21±5.89） vs （ 10.42 ±3.69） ] ,severity score[ （62.21±5.81 ） vs （22.26 ±4. 81 ） ] ,there were significant differences of every score of YGTSS between before and after treatment（ Pa 〈 0. 001 ）. Conclusion TPM is more effective,given in low dose in the treatment of TS with fewer side - effects,which may be selected firstly in the treatment of TS in children.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第12期936-937,947,共3页
Journal of Applied Clinical Pediatrics
