摘要
目的:探讨黛力新辅助奥美拉唑和吗叮啉治疗非糜烂性胃食管反流病(non erosive reflux disease,NERD)的临床疗效。方法:将85例NERD患者随机分为两组:治疗组(n=43)和对照组(n=42)。治疗组口服黛力新、奥美拉唑和吗叮啉,对照组口服奥美拉唑和吗叮啉。治疗前进行烧心、反酸和胸痛等反流症状评估,治疗8周后分别观察两组症状持续改善、临床疗效及不良反应发生情况,按疗效观察标准分析结果。结果:81例完成随访,治疗组2周末、4周末症状持续改善高于对照组,两组比较差异有显著性(P<0.05);8周末症状持续改善两组比较差异无显著性(P>0.05)。疗程结束后临床症状缓解,两组差异有显著性(P<0.05),两组不良反应总发生率差异无显著性(P=0.622)。结论:黛力新辅助奥美拉唑和吗叮啉治疗NERD优于奥美拉唑和吗叮啉,是治疗NERD的理想药物之一。
Objective：To observe the clinical effect of non-erosive reflux disease in 85 middle and aged patients treated by deanxit, omeprazole and domperidone.Methods：85 middle and aged patients with non-erosive reflux disease confirmed by endoscope were randomly divided into the treatment group （deamdt,omeprazole and domperidone,43 cases）and the control group （omeprazole and domperidone,42 cases ） .After 8 weeks of treatment,clinical symptoms as heartbum,chestpain,acid reflux and belching were observed respectively,the therapeutic effect were taken as criteria for comparison. Results：After 8 weeks of treatment,81 patients finished following, symptomatic remitted rate of the treatment group was significantly higher than that of controll group（P〈0.05）, persistent improvement of symptomatic remitted rate of the treatment group was significantly higher,than that of controll group in 2 and 4 weeks after treatment（P〈0.05）, persistent improvement of symptomatic remitted rate of the treatment group was not significantly higher than that of eontroll group in 8 weeks after treatment （P〉0.05）, there was no significant difference in the side effects between two groups （P〉0.05）.Conclusion： Deanxi, omeprazole and domperidone are more effective for treating non-erosive reflux disease.
出处
《现代医药卫生》
2007年第13期1906-1907,共2页
Journal of Modern Medicine & Health
