摘要
目的:探讨乙酰肝素酶在宫颈黏膜上皮内瘤变(CIN)与宫颈鳞癌中的表达。方法:应用免疫组化SP法检测乙酰肝素酶在56例CIN(CINⅠ12例,CINⅡ26例,CINⅢ18例),宫颈鳞癌54例(伴有淋巴结转移的20例)中的表达。结果:在CINⅠ,CINⅡ,CINⅢ组织中乙酰肝素酶阳性表达率分别为33.33%,38.48%,44.44%,宫颈鳞癌中乙酰肝素酶阳性表达率为48.14%。CIN与宫颈鳞癌的表达对比统计学无意义(P>0.05)。20例宫颈鳞癌伴淋巴结转移者,其癌组织内乙酰肝素酶阳性表达(70.00%)明显高于无转移组(35.29%),差异有显著性(P<0.01)结论:乙酰肝素酶表达与宫颈鳞癌发生、发展无关。与宫颈鳞癌淋巴结转移有关。
Objective： To investigate the expression of heparanase in cervical Intraepithelial neoplasia （CIN） and carcinoma of the cervix. Methods： Heparanase in 56 cases of CIN （ the cases included 12 CIN Ⅰ, 26 CIN Ⅱ, 18 CIN Ⅲ ） and 54 cases of carcinoma of the cervix were detected by immunohistochemical SP method. Results： The positive rates of expression of heparanase in CIN Ⅰ , CIN Ⅱ, CINⅢ and carcinoma of the cervix were respectively （33.33%, 38.48%; 44.44%;48.14% ）. The differences between CIN Ⅰ, CIN, CIN Ⅲ and carcinoma of the cervix were not significant（ P 〉 0.05） ; The increased expression of heparanase was observed in 20 cases of carcinoma of the cervix with lymph node metastasis（ 70.00% ）compared to those without metastasis（ 35.29% ）, it was significant different（P 〈 0.01）. Conclusion： There was no correlation between the expression of the heparanase and angiogenesis, progr-ession of carcinoma of the cervix . Heparanase expression were related with lymph node metastasis in carcinoma of the cervix.
出处
《河南大学学报（医学版）》
CAS
2007年第2期12-13,17,共3页
Journal of Henan University:Medical Science
基金
河南省教育厅自然科学研究项目(2006310001)
关键词
上皮内瘤变
宫颈鳞癌
乙酰肝素酶
转移
Intraepithelial neoplasia
carcinoma of the cervix
Heparanase
metastasis
