摘要
目的探讨吸烟对支气管哮喘患者血清白细胞介素(IL)和肿瘤坏死因子-α(TNF-α)的影响。方法选择2003年10月至2005年12月华北煤炭医学院附属医院呼吸内科门诊或住院的第3,4级支气管哮喘患者65例(哮喘组)和健康体检者50名(对照组),按吸烟史各分成吸烟组与无吸烟组,检测各组血清IL-2、IL-6、IL-8、IL-10和TNF-α,比较各组间差异及各指标的相关性。结果与对照组相比,哮喘组IL-2、IL-6、IL-8和TNF-α显著增高,IL-10显著降低(P均<0.01)。哮喘吸烟组IL-8和TNF-α明显高于哮喘非吸烟组(P<0.05,P<0.01)。对照吸烟组与对照非吸烟组IL-2、IL-6、IL-8、IL-10和TNF-α比较差异均无显著性意义(P均>0.05)。哮喘吸烟组IL-2、IL-8和TNF-α明显高于对照吸烟组(P均<0.01),而IL-10明显低于对照吸烟组(P<0.01),2组IL-6差异无显著性意义(P>0.05)。结论吸烟对哮喘患者体内细胞因子影响明显,吸烟的哮喘患者IL-8、TNF-α较非吸烟者增高。本研究测定的5种血清细胞因子变化与哮喘患者病情严重程度相关。
Objective To explore the influence of smoking upon the level of the serum interleukin and TNF-α in patients with bronchial asthma. Methods Sixty-five patients with bronchial asthma,grade 3 or 4 as asthma group and 50 healthy examinees as control group were selected. According to the smoking history, each group was divided into the smoking subgroup and the non-smoking subgroup. For each group,the level of cytokines in serum were detected,and at the same time, their smoking history and general condition were collected. The differences between the groups were compared and the relationship of all indexes was analyzed. Results Compared with the control group ,the level of IL-2 ,IL-6 ,IL-8 and TNF-α of the asthma group was significantly higher（ P 〈 0. 01 ） , but the level of IL-10 was significantly lower（ P 〈 0.01 ）. The level of IL-8 and TNF-α of the smoking asthma subgroup was significantly higher than the non-smoking asthma subgroup （P 〈0. 05 ,P 〈 0.01 ）. There was no significant difference between the smoking control subgroup and the non-smoking control subgroup in the level of IL-2 ,IL-6 ,IL-8 ,IL-10 and TNF-ct（P 〉0. 05 ）. The level of IL-2,IL-8 and TNF-α of the smoking asthma subgroup was significantly higher than the smoking control subgroup（ P 〈 0. 01 ） ,the level of IL-10 significantly lower（ P 〈 0.01 ） , but the level of IL-6 was not significantly different （ P 〉 0.05 ）. Conclusion The influence of smoking upon the level of cytokines of asthma patients is significant. The level of IL-8 ,TNF-α in serum of a smoking asthma patient increases. The level of five cytokines in serum of 65 asthma patients in our research is related to patient＇s condition severity.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2007年第13期1037-1039,共3页
Chinese Journal of Practical Internal Medicine
基金
河北省科技厅指导项目(0627619010)
