摘要
目的评价长期家庭氧疗对慢性肺源性心脏病(肺心病)低氧血症患者的疗效。方法缓解期肺心病低氧血症患者61例,均接受化痰、解痉、平喘等常规治疗,家庭氧疗(氧疗组)30例,双侧鼻导管吸氧,氧流量1～2L/min,氧疗时间10～15h/d;未进行家庭氧疗(对照组)31例。治疗前、治疗1年及2年分别测定周围血象、心电图、超声心动图评分。结果治疗2年后,氧疗组死亡7例,病死率23%;对照组死亡11例,病死率35%,差异无显著性意义(P>0.05);氧疗组在治疗1年和2年血红蛋白、红细胞计数和红细胞压积与治疗前无明显变化,对照组1年后的血红蛋白、红细胞计数和红细胞压积与治疗前比较无明显变化,2年后血红蛋白和红细胞计数高于治疗前(P<0.05);氧疗组1年和2年后心电图RV1+SV5与治疗前比较均无明显变化,对照组1年和2年后心电图RV1+SV5均高于治疗前(P<0.05),2年后高于1年后(P<0.05);超声心动图显示氧疗组1年和2年后的平均肺动脉压(mPAP)较治疗前下降(P<0.05),2年后低于1年后(P<0.05);2年后右心室流出道、右心室内径较治疗前减小(P<0.05),对照组1年和2年后的右心室内径、右心室流出道大于治疗前(P<0.05),2年后mPAP较1年后增加(P<0.05)。结论长期家庭氧疗可减轻心脏负荷,改善肺心病患者的生存质量。
Objective To evaluate the curative effect of long -term home oxygen therapy on patients suffering hypoxemia elicited by chronic pulmonary heart disease. Methods Sixty-one patients with hypoxemia following paracmasis pulmonary heart disease were received conventional therapies including expectorant, antispasmodic, and antiasthmatic. Among them, 30 patients were given home oxygen therapy （oxygen inhalation through a nasal catheter with the 02 flow rate of 1 -2L/min for 10 -15h/d） and other 31 patients were not given home oxygen therapy served as control. The peripheral blood assay, electrocardiogram, ultrasoun.dcardiogram were detected before, 1 year, and 2 years after treatment. Results After 2 year treatment, 7 patients died in home oxygen therapy group （23%） , whereas 11 died in control group （35%）. There was no significant difference between them （ P 〉 0.05 ）. The hemoglobin, red cell count, and haemat failed to show marked changes after 1 or 2 year treatment in compari- son with before treatment in oxygen therapy group. In control group, there were not significant changes in hemoglobin, red cell count, and haemat after 1 year treatment, but after 2 year treatment, the hemoglobin and red cell count were significantly higher than those of before treatment（ P 〈 0. 05 ）. RV1 ＋ SV5 on ECG did not change in oxygen therapy group after I or 2 year treatment as compared with before treatment; in control group, however, it elevated obviously （P 〈 0. 05）, higher in 2 years than 1 year（ P 〈 0.05 ）. In oxygen therapy group, the mean pulmonary arterial pressure reduced after 1 or 2 year treatment as compared with before treatment（ P 〈 0.05） , moreover it was subsequently lower after 2 .years than 1 year（ P 〈 0.05）. The right ventricular outflow and right ventricular internal dimension diminished after 2 year treatment as compared with before treatment in oxygen therapy group （ P 〈 0. 05 ） ; in control group, they were larger after treatment than before treatment （ P
出处
《实用医院临床杂志》
2007年第4期60-61,共2页
Practical Journal of Clinical Medicine
关键词
肺心病
家庭氧疗
生存质量
Pulmonary heart disease
Home oxygen therapy
Life quality
