摘要
目的观察二甲基亚砜(DMSO)、透明质酸酶(HAase)不同用药方法对多西紫杉醇外渗性皮肤损伤大鼠的疗效。方法30只SD大鼠随机分为6组,每组5只,每只大鼠双后肢造成多西紫杉醇血管外渗模型后,分别外涂DMSO、局部注射HAase、HAase局部注射联合DMSO外涂、外涂生理盐水(NS)、局部注射NS及模型对照组不作任何防治干预。观察各组大鼠多西紫杉醇外渗性损伤程度和损伤愈合时间。结果各组大鼠损伤程度有差异,其中DMSO组、HAase组及联合用药组的损伤程度较轻,NS外涂组、NS注射组和模型对照组的损伤程度较重。DMSO组的损伤愈合时间为19.10±2.13天,显著短于NS外涂组23.70±2.41天和模型对照组25.70±2.26天(P<0.01)。HAase组和HAase联合DMSO组的损伤愈合时间为12.00±3.00天和14.40±2.30天,显著短于其他4组的愈合时间(P<0.01),但该两组间无显著性差异。结论DMSO外涂或HAase单独局部注射均可降低多西紫杉醇外渗性损伤程度,缩短损伤愈合时间,具有良好的疗效。联合用药未能提高疗效。
Objective The purpose of present study was to compare the efficacy of topical dimethyl sulfoxide （DMSO）, intralesional hyaluronidase （HAase） and intmlesional HAase plus topical DMSO on skin damage caused by docetaxel extmvasation in a rat model. Methods After the establishment of animal model of docetaxel extravasation on each hind limb in 30 SD rots, the animals were assigned randomly into 6 groups with 5 rats for each group： topical DNL.qO group （TD）, intralesional HAase group （IH）, IH plus TD group （IH ＋TD）, topical normal saline group （tNS）, intralesional NS group （iNS）, and control group （C）. The extent of skin damage and the heal ing time were observed and compared. Results The extent of skin damage was different among the 6 groups： severer skin damage was seen in tNS, iNS and C groups compared with TD, IH and IH＋TD groups. The healing time was significantly shorter in TD group than in both tNS and C groups [（19. 10±2. 13）d vs （23. 70±2. 41）d and （25. 70±2. 26）d, P〈0. 01]. The healing time in IH group [（12.00±3. 00）d] or in IH＋TD group [（14. 40±2. 30）d] was significantly shorter than that in other 4 groups （ P〈0. 01）, but no significant difference existed between the former two groups. Conclusions The monotherapy of topical DMSO or intralesional HAase is efficient in treating the skin damage caused by docetaxel extravasation since the extent of skin damage is attenuated and the healing time decreased. A combined administration of intralesional HAase plus topical DMSO may not be better than the monotherapy with intralesional HAase.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2007年第6期588-590,共3页
Medical Journal of Chinese People's Liberation Army
关键词
二甲基亚砜
透明质酸酶
多西紫杉醇
诊断和治疗物质外渗
dimethyl sulfoxide
hyaluronidase
docetaxel
extravasation of diagnostic and therapeutic materials
