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作为生物探针的噻唑橙类化合物的合成及光谱性质研究

Synthesis and spectral properties of thiazole orange compounds as biological probes
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摘要 以6-甲基-2-氨基苯并噻唑为原料,合成了噻唑橙染料的一个衍生物,并比较了它与其他两种噻唑橙类染料的光谱性质,讨论了取代基的引入对于染料光谱性质的影响.结果表明,与噻唑橙相比,在分子中引入甲基后,染料的最大吸收波长发生红移;与蛋白结合后最大吸收波长红移,荧光最大波长蓝移. A derivative of the dye thiazole orange was synthesized using 6-methyl-2-aminobenzothiazole as a raw material. Spectral properties of this compound were compared to the two dyes prepared in our previous work. The Influence of introducing groups on the spectrum of the dye was discussed. Results show that, as compared with thiazole orange, the introduction of methyl to the molecule makes bathochromical shift of absorption maximum of the dye. In addition, binding of BSA protein with the molecule leads to the bathochromical shift of absorption maximum and hypsochromical shift of fluorescent maximum of the dye.
出处 《天津理工大学学报》 2007年第3期8-12,共5页 Journal of Tianjin University of Technology
基金 教育部重点科技基金(ID:205013)
关键词 生物探针 6-甲基-2-氨基苯并噻唑 噻唑橙 光谱性质 biological probe 6-methyl-2-aminobenzothiazole thiazole orange spectral properties
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参考文献8

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二级参考文献7

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