摘要
目的探讨应用大分割三维适形放射治疗（3DCRT）中晚期肝癌的价值。方法对20例原发性肝癌采用3DCRT治疗,设5-6个共面或非共面适形野,≥90%的等剂量线包括计划靶体积（PTV）,PTV 3-5 Gy/次,每周3-5次,共10-15次完成,总剂量45-55Gy。治疗后2个月复查CT或MRI,根据肿瘤退缩情况评价疗效。结果完全缓解率（CR）15%（3/20）,部分缓解率（PR）65%（13/20）,无变化（NC）15%（3/20）,加重（PD）5%（1/20）,总有效率（CR＋PR）达80%。消化道副反应95%（18/20）,以Ⅰ-Ⅱ级为主,肝功能异常33%（6/20）。结论大分割三维适形放射治疗中晚期肝癌安全、副作用小,近期疗效确切。
Objective To explore the value of hyperfractionated three-dimensional conformal radiotherapy （3DCRT） for advanced hepatocellular carcinoma. Methods 20 patients with advanced hepatocellular carcinoma who were treated with 3DCRT received a total dose of 45-55Gy with 5-6 conformal fields, 3-5Gy/fraction, 3-5 fractions/week, totally 10-15 fractions. All patients had liver scan by CT or MRI after two months. The treatment effects were evaluated according to the image. Results The complete remission （CR） was 15% （3/20）, partial remission （PR） was 65% （13/20）; no change （NC） was 15% （3/20） and progression disease （PD） was 5% （1/20）.The total response rate （CR ＋ PR） was 80%. Conclusion The hyperfractionated three-dimensional conformal radiotherapy for advanced hepatocellullar carcinoma is Safe and less toxicity. It has actual early effects on advanced hepatocellullar carcinoma.
出处
《宁夏医学院学报》
2007年第3期256-257,共2页
Journal of Ningxia Medical College
关键词
肝脏
肿瘤
放射疗法
三维适形
liver
neoplasms
radiotherapy
three dimensional
