摘要
骨骼肌的收缩特性部分是由肌球蛋白重链(MHC)亚型决定的。脊髓损伤后损伤水平以下的骨骼肌MHC各亚型mRNA和蛋白水平发生适应性变化,表现为慢MHC-Ⅰ亚型表达下调,快MHC亚型表达上调。MHC-mRNA的适应性变化先于蛋白的变化。不同物种、不同肌肉MHC转化的程度与速度不同。脊髓损伤后短时间训练不能引起MHC亚型发生显著的转化,而长期负重步行训练能够减缓肌纤维MHC亚型表达发生由慢向快的转化。
Skeletal muscle contractile properties are determined by their myosin heavy chain （MHC） expression profiles partly. Spinal cord injury induced the adaptation change in MHC isoform mRNAs and protein expression of skeletal muscle below the injured level, leading to the increased expression of fast and decreased expression of slow MHC isoforms. The adaptations in the MHC-mR- NAs preceded the changes in proteins. The degree and velocity of MHC isoform adaptation were dependent on differenrt muscle and animal species. Short-term training could not induce the significant change of the transformation of MHC isoform, whereas long-term stepping training which emphasized load bearing could attenuate the MHC shift from slow toward faster isoforms.
出处
《中国康复理论与实践》
CSCD
2007年第6期508-510,共3页
Chinese Journal of Rehabilitation Theory and Practice
关键词
脊髓损伤
肌萎缩
肌球蛋白重链
训练
综述
spinal cord injury
muscle atrophy
myosin heavy chain
training
review
