摘要
目的:应用动态血压监测(ABPM)的方法比较两种钙拮抗剂(盐酸贝尼地平与非洛地平缓释片)治疗原发性高血压的疗效。方法:选择原发性高血压患者83例,随机分为两组,贝尼地平组41例,晨起口服贝尼地平1次/d,初始剂量4 mg;非洛地平缓释片(波依定)组42例,晨起口服波依定1次/d,初始剂量5 mg。两组1周后血压未达显效者,剂量增加1倍。结果:治疗4周后,两组血压均有明显下降,用药前后相比均有显著差异(P(0.01)。贝尼地平组为总有效率82.93%,降压谷/峰(T/P)值SBP为65.00%,DBP为62.50%;非洛地平缓释片组总有效率为83.33%,降压T/P值SBP为66.45%,DBP为67.63%。两组间比较差异无统计学意义(P(0.05)。药物不良反应两组间无统计学差异。结论:盐酸贝尼地平或非洛地平缓释片治疗原发性高血压疗效肯定,未见明显不良反应,适合临床使用。
OBJECT To compare the clinical efficacy of two calcium antagonists （ Benidipine and Felodipineon ） for essential hypertension using ambulatory blood pressure monitoring. METHOD Patients were randomly divided into two groups ,41 in the benidipine group and 42 in the felodipine group. They were treated by benidipine and slow - released felodipine for 4 weeks. RESULT At the end of the treatment ,blood pressure of two groups fell markedly （ P 〈 0.01 ）. The total effective rate of two groups was 82.93% （Benidipine） and 83.33% （ Felodipine） respectively. There were no remarkable differences in two groups. The mean trough/peak ratio in Benidipine group and Felodipine group was for SBP 65.00% and 66.45%, for DBP 62.50% and 67.63% respectively. Adverse reaction showed difference rarely in statistical significance. CONCLUSION Benidipine [4 - 8 mg/d once a day） can decrease blood pressure smoothly in same speed for 24 hrs as felodipine （5 - 10 mg/d once a day）. Both drugs are safe and effective in the treatment of hypertension.
出处
《天津药学》
2007年第3期41-43,共3页
Tianjin Pharmacy
关键词
贝尼地平
非洛地平缓释片
动态血压监测
Benidipine, slow- released felodipine, ambulatory blood pressure monitoring
