摘要
目的测定和比较6种不同的有机和无机钙剂的真正吸收率和生物利用度。方法采用同位素稀释技术。在2w的代谢研究中,60只生长期雄性SD大鼠,肌肉注射45Ca后,分为6组,每组10只,分别饲喂含柠檬酸钙、乳酸钙、醋酸钙、牡蛎壳粉、蛋壳粉和β-磷酸三钙的人工半合成饲料。6种饲料中含钙、磷、镁的量均相同,分别为2.8,5.3和0.65g/kg。结果柠檬酸钙、乳酸钙和醋酸钙等有机形式钙的真正吸收率和生物利用度(真正吸收率分别为98.8,98.3和98.6%;生物利用度分别为96.8,96.0和96.8%)略高于生物碳酸钙类的牡蛎壳和蛋壳(真正吸收率分别为97.7和96.3%;生物利用度分别为95.3和93.8%)以及无机类的β-磷酸三钙(94.9和92.0%)。然而,从实际应用角度衡量,所观察的6种钙剂均显示很高的吸收率和生物利用度。结论可以认为,膳食钙的化学形式并不是影响钙生物利用度的主要因素。
Objective Determination and comparison of calcium true absorption and bioavailability of six different organic and inorganic dietary Ca sources by isotope dilution technique. Methods In a 2-week metabolic study, 60 ^45Ca labeled growing SD rats, divided into six groups, each of 10 were fed restrictively a semisynthetic purified diet supplemented with calcium citrate, calcium lactate, calcium acetate, oyster-shell meal, eggshell meal and β- tri-Ca phosphate. The total dietary contents of Ca, P and Mg were uniformly 2.8, 5.3 and 0.65 g/kg. Results True absorption, intermediate utilization and bioavailability was uniform for Ca citrate, lactate and acetate （true absorption ： 98.8,98.3 and 98.6 % ; bioavailability ： 96.8,96.0 and 96.8 % ）. Oyster-shell and eggshell revealed only slight lower values （true absorption 97.7 and 96.3% ;bioavailability： 95.3 and 93.8）. β-tri-Ca phosphate were lower in bioavailability （92.0%）. However, in total, all tested Ca sources revealed high absorbability and utilizability. Conclusions The chemical formulation of dietary Ca does not seems to be the primary factor of Ca bioavailabily in practical diets.
出处
《中国骨质疏松杂志》
CAS
CSCD
2007年第6期377-380,共4页
Chinese Journal of Osteoporosis
关键词
柠檬酸钙
乳酸钙
醋酸钙
牡蛎壳
蛋壳
吸收率
生物利用度
同位素稀释技术
Ca citrate
Ca lactate
Ca acetate
Oyster-shell
Eggshell
Absorption
Bioavailability
Isotope dilution technique
