摘要
目的探讨亚临床肝性脑病(SHE)早期诊断的方法。方法对46例肝硬化无肝性脑病临床表现的患者进行P300、脑干听觉诱发电位(BAEP)、数字连接测验(NCT)、简明智力状况检查量表(MMSE)及脑电图(EEG)检测和随访,并与43例非肝病患者进行比较。结果肝硬化组P300潜伏期、NCT时间较对照组明显延长(均P<0.01);BAEP异常率明显增加(P<0.01);随肝功能损害程度加重,P300潜伏期逐级显著延长、波幅显著降低,NCT时间显著延长,BAEP异常率显著增加(P<0.05～0.01)。随访发现P300、BAEP或NCT异常的肝硬化患者HE发生率间差异无统计学意义。结论P300、BAEP及NCT可作为早期诊断SHE的检测方法。
Objective To investigate the early diagnostic methods for sub-clinical hepatic encephalopathy （SHE）. Methods 46 hepatocirrhosis patients without hepatic encephalopathy （SHE group） were recruited to perform P300, brainstem auditory evoked potential （BAEP）, numeral connection teat （NCT）, mini-mental state examination （MMSE）and electroencephalogram （EEG）, compared with 43 unhepatopathy patients （control group） and within following up. Results The P300 delitescence and the NCT value in SHE group were obviously longer than those of the control group （ all P 〈 0.01 ） , and so the abnormal rate of BAEP was higher （ P 〈 0.01 ）. As the damage of liver function worsened, the values of P300 delitescence and NCT became longer, the value of P300 amplitude became lower, and the abnormal rate of BAEP rised obviously （ P 〈 0.05 - 0.01 ）. With following up, there was no significant difference among the patients with abnormal P300 delitescence, BAEP or NCT in incidonce of sub-clinical hepatic encephalopathy. Condusion P300, BAEP and NCT can be peformed as the early diagnostic methods for SHE.
出处
《临床神经病学杂志》
CAS
北大核心
2007年第3期227-229,共3页
Journal of Clinical Neurology
关键词
肝性脑病
亚临床
P300
脑干听觉诱发电位
数字连接测验
hepatic encephalopathy, sub-clinical
P300
brainstem auditory evoked potential
numeral connection test
