摘要
为了寻求一种适宜的石棉表面改性剂，利用体外细胞培养技术，通过测定培养液中亚硝酸根（ＮＯ－２）含量，观察了茫崖产温石棉对豚鼠肺泡巨噬细胞（ＡＭ）产生一氧化氮（ＮＯ）的诱导作用以及混合稀土、亚硒酸钠、柠檬酸铝对石棉诱发ＡＭ产生ＮＯ的影响。结果显示，温石棉纤维可使培养液中ＮＯ－２浓度升高，并呈明显的剂量反应关系；混合稀土、亚硒酸钠、柠檬酸铝均可抑制石棉诱发ＡＭ产生ＮＯ，而且随上述化合物浓度的升高，抑制作用增强。提示用混合稀土和亚硒酸钠拮抗石棉的致病作用有实际应用的可能。
Induction of chrysotile produced in Mang ai to the production of nitrogen oxide (NO) and effects of mixed rare earths (MRE), sodium selenite (SS) and aluminium citrate on the production of NO in alveolar macrophage (AM) induced by asbestos fiber were observed by in vitro cell culture technique and determination of nitrite ion content in the culture medium. Results showed that chrysotile fiber could increase nitrite ion content in the culture medium, with an obvious dose dependent relationship. MRE, selenite, and aluminium citrate all could inhibit the production of NO in AM induced by asbestos, and its inhibitiory effects increased with the concentration of the above mentioned chemicals. It suggests antagonism of MRE and selenite to pathogenicity of asbestos may be used in practice.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
1997年第1期31-33,共3页
Chinese Journal of Preventive Medicine
