摘要
目的 观察三氧化二砷（As2O3）联合全反式维甲酸（ATRA）治疗急性早幼粒细胞白血病（APL）的疗效和不良反应。方法 对APL28例患者用ATRA25mg·m^-2·d^-1，分2～3次服用，As2O3 0．28mg·m^-2·d^-1静脉点滴，并根据外周血白细胞数、不良反应等调整ATRA和As2O3用量直至完全缓解（CR）。结果 28例患者中，2例因发生DIC合并脑出血死亡，26例患者CR，CR率92．9％（26／28）；取得CR所需治疗时间为（22．8±4．5）d（18～36）d。85．7％患者在治疗开始时白细胞升高；46．4％出现肝功异常，多在As2O3减量或停用后1周内恢复。结论 ATRA联合As2O3治疗APL疗效好，不良反应少，CR时间短。
Objective To observe the efficacy and side effect of the all-trans retinoic acid（ATRA） and arsenic trioxide （As2O3） combination in acute leukemia （APL）. Methods 28 patients were treated with As2O3 （0.28mg/kg for intravenous drop in 4 to 6 hours once a day）. And ATRA were taken orally 25mg/m^2 every day（in two or three separate doses） until complete remission （CR）. The doses were adjusted by white blood cell （WBC） count and side effects. Results Except two patients died early,26 of the 28 patients achieved CR,the percent of CR rate was 92.9 %. The average time for achieving CR was （22.8 ± 4.5） days. Hyperleukocytosis emerged in 85.7 % and hepatic damages in 46.4 % of the patients,they were ameliorated within one week after reduction of the As2O3 dose or its suspension. Conclusion The combination of As2O3 and ATRA in the treatment of APL can obtain a higher CR rate without intolerable side effects and a shorter duration for achieving CR.
出处
《中国基层医药》
CAS
2007年第5期751-753,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
维甲酸
砷剂
白血病
早幼粒细胞
急性
Tretinoin
Aresnicals
Leukemia, promyelocytic, acute
