摘要
目的:探讨中药血脂康胶囊(红曲)对儿童肾病综合征(NS)的辅助治疗效果。方法:选择58例临床诊断为原发性肾病综合征(单纯型)的患儿,随机分为两组,其中治疗组30例,对照组28例。两组患儿均采用强的松中长程疗法,治疗组同时加用血脂康口服,服药前及服药8周后测定血脂、微量元素、白蛋白及肾功能等指标,对所有患儿均长期随访。结果:治疗组在服用血脂康8周后血清总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)以及甘油三酯(TG)降低而高密度脂蛋白-胆固醇(HDL-C)增加(P<0.01),同时血清锌、铜、铁、镁含量增加(P<0.01),与对照组比较差异有统计学意义(P<0.05);治疗组尿蛋白转阴时间短于对照组,复发率(20.0%)低于对照组(46.4%) (P<0.05)。结论:血脂康胶囊能有效改善NS患儿的各项血脂指标.使血清微量元素恢复正常水平,早期应用可减轻肾损害,缩短激素疗程,降低复发率。
Objective ：To investigate the effects of Xuezhikang capsules （red kojic） as an adjunctive therapy on children＇s nephrotic syndrome. Methods： 58 children with primary nephrotie syndrome were divided into two groups at random： 30 cases in the treatment group and 28 cases in the control group. Both groups were treated with a routine procedure of prednisone. At the same time the treatment group was given the drug of Xuezhikang capsules, Serum lipids, trace elements, urinary protein, kidney function and etc. were measured 8 weeks before and after the treatment. All children had long term follow-ups. Results： 8 weeks after Xuezhikang capsules given, the level of serum TC, LDL-C and TG were decreased （ P 〈 0.01 ） while serum HDL-C increased （P 〈0.01）, meanwhile the percentage of Zn, Cu, Fe and Mg significantly increased; the days needed for urinary protein to turn to negative was less than that of the control group and the recrudescence rate （20.0%） was also lower than that of the contrastive group （46.4%） （P 〈0.05）. Conclusions： Xuezhikang capsules can effectively improve the hyperlipidemia on children＇s nephrotic syndrome. It decreased the percentage of trace elements to its normal level, and early application of Xuezhikang capsules can not only reduce the harm to kidney but also shorten the period of treatment and reduce the recrudescence rate.
出处
《儿科药学杂志》
CAS
2007年第3期43-45,共3页
Journal of Pediatric Pharmacy
关键词
儿童
肾病综合征
血脂康胶囊
高脂血症
微量元素
Children
Nephrutic syndrome
Xuezhikang capsule
Hyperlipidemia
Trace element
